Effects of Palm Olein Versus Olive Oil on Blood Lipids, Lipoproteins and Novel Risk Markers of Cardiovascular Disease
试验速览
- 阶段
- 不适用
- 入组人数
- 45
- 试验地点
- 2
- 主要终点
- total, HDL, LDL cholesterol and triacylglycerol
研究概览
简要总结
The aim of this study is to compare the effects of a diet rich in palm olein, a fraction of palm oil, to a diet rich in olive oil and a diet rich in Danish lard on plasma total-, LDL and HDL cholesterol as well as triacylglycerol (TAG), fasting insulin and glucose, C reactive protein and plasminogen activator inhibitor 1 in healthy men. The investigators hypothesis is that palm olein and olive oil will have the same effect on plasma total cholesterol, LDL- and HDL concentration and maybe also on the secondary outcome parameters that are related to cardiovascular disease risk. This may be caused by the differences in the sn-positioning of palmitic acid in palm olein. This difference may cause the palmitic acid in palm olein to be more prone to soap formations and excretion than palmitic acid from other sources, e.g. lard.
This study is a double blinded, randomized, controlled 3 x 3 week crossover intervention study, without washout periods. The participants receive the three test foods in random order, decided by draw of lots. Blood samples are drawn in duplicate (on two following days) before and after each dietary period.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •All participants must give their informed consent in writing, after having received oral and written information about the study
- •Age: 18-65 y
- •BMI: 18.5 - 30 mg/m2
- •Healthy (no known diseases, incl. hypertension, hypercholesterolemia, diabetes and psoriasis)
- •No use of dietary supplements or blood donations two month prior to and during the intervention
排除标准
- •Current or previously cardiovascular disease
- •Diabetes Mellitus or other severe chronic disease, including severe allergies and psoriasis
- •Hypertension
- •Known or suspected abuse of alcohol, drugs or medication
- •Own request: all participants have the right to withdraw from the intervention at any given time without explanation
- •Compliance: participants may be excluded from the intervention if they do not follow the study guidelines
- •Side effects (There are no side effects expected in this study since all test fats are commercial available and use in households world wide)
结局指标
主要结局
total, HDL, LDL cholesterol and triacylglycerol
时间窗: before and after each type of dietary fat
次要结局
- fasting insulin and glucose, c reactive protein and plasminogen activator inhibitor 1(befoer and after each dietary test fat)