Effect of Amino Acids and Sugar Alcohols on Satiation Peptides and Activation of Specific Brain Regions
Not Applicable
Completed
- Conditions
- Endocrine System Diseases
- Registration Number
- NCT02823249
- Lead Sponsor
- University Hospital, Basel, Switzerland
- Brief Summary
With this study the investigators investigate the effects of amino acids (tryptophan, leucin) and sugar alcohols (xylitol, erythritol) on satiety mechanisms and brain activation.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 20
Inclusion Criteria
- Healthy normal weight subjects with a body-mass index of 19.0-24.9
- Healthy obese subjects with a body-mass index of > 30
- Normal eating habits (no diets; no dietary changes; no special dietary habits such as vegetarian/vegan)
- Age 18-40 years
- Stable body weight for at least three months
Exclusion Criteria
- Smoking
- Substance abuse
- Regular intake of medications (except for oral contraceptives)
- Medical or psychiatric illness
- History of gastrointestinal disorders
- Food allergies
- Pregnancy, breast feeding
- Body piercings that cannot be removed
- History of claustrophobia
- Left-hander
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Primary Outcome Measures
Name Time Method Effect of aminoacids on cerebral blood flow measured by functional brain MRI changes from baseline to one hour after treatment Effect of sugar alcohols on cerebral blood flow measured by functional brain MRI changes from baseline to one hour after treatment
- Secondary Outcome Measures
Name Time Method Measurement of Plasma PYY concentrations changes from baseline to three hours after treatment Measurement of Plasma ghrelin concentrations changes from baseline to three hours after treatment Measurement of Plasma Glucose concentrations changes from baseline to three hours after treatment Measurement of Plasma Insulin concentrations changes from baseline to three hours after treatment Measurement of Plasma cholecystokinin concentrations changes from baseline to three hours after treatment Measurement of Plasma Glucagon-like Peptide (GLP-1) concentrations changes from baseline to three hours after treatment
Trial Locations
- Locations (1)
University Hospital Basel
🇨🇭Basel, Basel-Stadt, Switzerland
University Hospital Basel🇨🇭Basel, Basel-Stadt, Switzerland