Effect of Amino Acids and Sugar Alcohols on Gastric Emptying and Release of Satiation Peptides in Humans

Not Applicable

Completed

• Conditions: Endocrine System Diseases

• Registration Number: NCT02563847
• Lead Sponsor: University Hospital, Basel, Switzerland

Brief Summary

With this study the investigators investigate the effects of amino acids (tryptophan in two different concentrations, leucin) and sugar alcohols (xylitol, erythritol) on satiety mechanisms.

Detailed Description

Not available

Study Timeline

• Study Start: 2014-05
• Primary Completion: 2015-03
• Study First Submitted: 2015-05-26
• Status Verified: 2015-09
• Study First Submitted QC: 2015-09-28
• Last Update Submitted: 2015-09-28
• Study First Posted: 2015-09-30
• Last Update Posted: 2015-09-30

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

• Healthy normal weight subjects with a body-mass index of 19.0-24.9
• Healthy obese subjects with a body-mass index of > 30
• Normal eating habits (no diets; no dietary changes; no special dietary habits, such as vegetarian/vegan)
• Age 18-40 years
• Stable body weight for at least three months

Exclusion Criteria

• Smoking
• Substance abuse
• Regular intake of medications (except for oral contraceptives)
• Medical or psychiatric illness
• History of gastrointestinal disorders
• Food allergies
• Pregnancy, breast feeding

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Primary Outcome Measures

Name	Time	Method
Effect of different aminoacids and sugar alcohols on secretion of satiation hormones	changes from baseline to three hours after treatment	Plasma concentrations of cholecystokinin are measured

Secondary Outcome Measures

Name	Time	Method
Effect of different aminoacids and sugar alcohols on gastric emptying	changes from baseline to four hours after treatment	measured by C13 breath test

Trial Locations

Locations (1)

University Hospital Basel, Phase 1 Research Unit; 🇨🇭 Basel, Switzerland