ocal Responses to Food Allergens in Eosinophilic Esophagitis: Mechanisms and Clinical Application

Amsterdam UMC, Location AMC0 个研究点目标入组 12 人开始时间: 待定最近更新: 2024年2月28日

适应症

试验速览

•Previous diagnosis of active EoE confirmed by histopathology e.g. presence of >15 eosinophilic granulocytes per high power field (hpf) in mid or proximal esophageal biopsies
•-Written informed consent
•-Age 18 – 75 years

•-Inability to stop topical corticosteroids
•-Inability to stop beta-blockers and ACE inhibitors
•-Use of oral or systemic antihistaminics, oral cromoglicates, systemic corticosteroids, leukotriene inhibitors, or monoclonal antibodies, in the month preceding the study
•-Proven gastroesophageal reflux disease or other cause for esophageal eosinophilia
•-History of peptic ulcer disease
•-History of Barrett’s esophagus
•-History of GI cancer
•-ASA class III, IV or V
•-History of anaphylaxis
•-History of a severe systemic reaction to previous allergy tests (grade 3 or 4)

发起方

Amsterdam UMC, Location AMC