ocal Responses to Food Allergens in Eosinophilic Esophagitis: Mechanisms and Clinical Application - LOIRE-trial

Academisch Medisch Centrum0 个研究点目标入组 18 人开始时间: 待定最近更新: 2024年4月15日

适应症

试验速览

暂无简介。

•Eosinophilic esophagitis patients
•- Previous diagnosis of active EoE confirmed by histopathology e.g. presence of
•> 15 eosinophilic granulocytes per high power field (hpf) in mid or proximal
•esophageal biopsies
•- Written informed consent
•- Age 18-75 years
•Non- eosinophilic esophagitis patients
•- Patients that undergo a gastroscopy for other indications than esophageal
•- Written informed consent
•- Age 18 * 75 years

•Eosinophilic esophagitis patients
•- Inability to stop topical corticosteroids
•- Inability to stop beta-blockers and ACE inhibitors
•- Use of oral or systemic antihistaminics, oral cromoglicates, systemic
•corticosteroids, leukotriene inhibitors, or monoclonal antibodies, in the month
•preceding the study
•- Proven gastroesophageal reflux disease or other cause for esophageal
•eosinophilia
•- History of peptic ulcer disease
•- History of Barrett*s esophagus
•- History of GI cancer
•- ASA class III, IV or V
•- History of anaphylaxis
•- History of a severe systemic reaction to previous allergy tests (grade 3 or 4)
•Non- eosinophilic esophagitis patients
•- Symptoms of esophageal dysfunction
•- History of esophageal diseases

发起方