Coronary Atherosclerosis Evaluation by Arterial Wall Magnetic Resonance Imaging (MRI)

Not Applicable

Completed

• Conditions: Coronary Arteriosclerosis; Arteriosclerosis, Coronary; Atherosclerosis, Coronary; Coronary Artery Disease; Coronary Atherosclerosis

• Registration Number: NCT00353795
• Lead Sponsor: Johns Hopkins University

Brief Summary

The overall goal of this study is to use MRI to:

* Examine the relationship between known risk factors for cardiovascular disease and coronary artery wall thickness;

* Examine the relationship between coronary artery wall thickness and other markers of subclinical coronary atherosclerosis, such as carotid wall thickness and coronary calcium scores; and,

* Examine the feasibility of measuring the progression of coronary artery wall thickness over time in a subset of participants.

Detailed Description

Each enrolled participant will undergo MR Imaging of the coronary arteries in conjunction with their routine MESA follow-up visit. The MRI will last approximately 45-60 minutes

Study Timeline

• Study Start: 2005-07
• Study First Submitted: 2006-07-18
• Study First Submitted QC: 2006-07-18
• Study First Posted: 2006-07-19
• Primary Completion: 2008-06
• Study Completion: 2008-06
• Results First Submitted: 2009-08-04
• Status Verified: 2009-09
• Results First Submitted QC: 2010-05-25
• Last Update Submitted: 2010-05-25
• Results First Posted: 2010-06-22
• Last Update Posted: 2010-06-22

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 179

Inclusion Criteria

• Prior enrollment in the MESA Study at the Hopkins MESA Field Center or the Northwestern University MESA Field Center
• Male or Female adult equal to or older than 45 years of age
• Willing/able to provide informed consent

Exclusion Criteria

• Any known contraindications to MRI (i.e. severe claustrophobia, pacemaker, etc.)
• Metal in the eyes

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Primary Outcome Measures

Name	Time	Method
Mean Coronary Wall Thickness	n/a (cross sectional analysis)	Average thickness of the wall of the left anterior descending, right and left main coronary artery measured by magnetic resonance imaging (MRI).

Trial Locations

Locations (2)

Northwestern University MESA Field Center; 🇺🇸 Chicago, Illinois, United States

Johns Hopkins MESA Field Center; 🇺🇸 Baltimore, Maryland, United States