Macronutrients and Gut Hormone Secretion
- Conditions
- Type 2 Diabetes
- Interventions
- Other: Macronutrients
- Registration Number
- NCT01366794
- Lead Sponsor
- Lund University
- Brief Summary
Study hypothesis is to examine the relative contribution of macronutrients for gut hormone secretion after a mixed meal in healthy volunteers and in subjects with type 2 diabetes. Individual macronutrients or a mixed meal will therefore be served and gut hormones are measured during the following 300 min.
- Detailed Description
In healthy volunteers and subjects with dietary regulated diabetes mellitus, glucose, protein mixture or fat emulsion will be served individually and on a separate occasions a mixed meal will be served. Samples will be taken during the following 300 min. Concentrations of the gut hormones glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1, insulin and glucagon will be determined.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 36
- Healthy status or type 2 diabetes with dietary regulation
- Liver disease
- kidney disease
- thyroid disease
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- FACTORIAL
- Arm && Interventions
Group Intervention Description Type 2 diabetes Macronutrients Administration of macronutrients in type 2 diabetes Healthy volunteers Macronutrients Administration of macronutrients in healthy volunteers
- Primary Outcome Measures
Name Time Method Release of gut hormones 300 min
- Secondary Outcome Measures
Name Time Method Insulin secretion 300 min
Trial Locations
- Locations (2)
Lund University
🇸🇪Lund, Sweden
Department of Clinical Sciences Lund, Lund University
🇸🇪Lund, Sweden