on-medical prescription opioid use and its neuropsychological predispositions and consequences.

• Conditions: on-medical prescription opiod users; F11.2

• Registration Number: DRKS00009039
• Lead Sponsor: Psychiatrische Universitätsklinik ZürichExperimentelle und Klinische Pharmakopsychologie

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2015-08-12
• Study Completion: 2018-01-05
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 59

Inclusion Criteria

Proficiency in German language
- Absence of acute or prior physical illness and psychiatric disorders - opioid dependent subjects or healthy drug-naïve controls

Exclusion Criteria

- Polydrug consumption
- presence of neurological disorders or brain injury

Study & Design

• Study Type: observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Social cognition (i.e. empathy, theory of mind, and emotion perception abilities) will be assessed by using Movie of the Assessment for Social Cognition (MASC), Multifaceted Empathy Test (MET), and Comprehensive Affect Test System (CATS). Social pain as ostracism will be measured by the Cyberballl task and empathy for pain will be examined by the Empathy for Pain task. Endocrinological parameters (cortisol, alpha amylase, ACTH, and oxytocin) will be assessed by saliva and blood samples during the last two tasks. Additionally, electrophysiological stress responses as skin conductance response and heart rate will be recorded. Six months later, participants will be re-invited for a follow-up testing session depending on subjects availability. The procedure and examination as well as the experimental environment will be equal to the first visit (parallel version of the tests will be conducted if applicable).

Secondary Outcome Measures

Name	Time	Method
The assessment of cognitive functioning will contain the following subtests of the CANTAB test battery: Rapid Visual Processing (RVP) for sustained attention, Paired Associates Learning (PAL) for visuo-spatial memory, Spatial Working Memory (SWM) for working memory/executive functioning, Intra-/Extradimensional set shifting (IED) for executive functions, and Stop-Signal Task (SST) for measuring impulse control. Additional cognitive task will be: Rey Auditory Verbal Learning Test (RAVLT) for verbal memory, Letter Number Sequencing Task (LNST) for working memory, and Delay Discounting task (DD) for decision making and impulsivity.