Persistent opioid use and opioid-related harm after hospital admissions for surgery and trauma in New Zealand- a population-based retrospective cohort study

Not Applicable

Completed

• Conditions: Trauma; Surgery; Pain; Public Health - Epidemiology; Anaesthesiology - Pain management; Injuries and Accidents - Fractures; Emergency medicine - Other emergency care; Surgery - Other surgery

• Registration Number: ACTRN12620000924954
• Lead Sponsor: Amy Chan

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2020-09-17
• Study Completion: 2021-09-30
• Last Update Posted: 29 May 2023

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 524945

Inclusion Criteria

The study population includes all opioid-naïve patients (of any age) who had a surgical procedure and/or were presented to the hospital with trauma in one of NZ’s 39 public hospitals between 1st January 2007 and 31st December 2019.

Exclusion Criteria

1) those who have evidence of a surgical procedure and/or traumatic event in 365 days prior to the index date; 2) those who underwent more than one surgical procedure type on the day of surgery; and 3) those with evidence of opioid use disorders (e.g. overdose, misuse or dependence) or opioid prescriptions in 180 days prior to the index date.

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Persistent use of opioids after trauma or surgery as assessed via pharmacy dispensing claimant database (Pharmaceutical collection). Persistent opioid use will be defined as additional pharmacy claims for one or more opioid prescriptions 91 days to 365 days after date of hospital discharge[Persistent opioid use will be defined as additional pharmacy claim for one or more opioid prescription 91 days to 365 days after the date of hospital discharge. Patients who filled one or more opioid prescriptions within 90 days after the hospital discharge date but did not fill between 91 and 365 days will be considered as non-persistent opioid users, as the duration of use is time-limited so cannot be considered as chronic (persistent) use.]