Opioid PrEscRiptions and Usage After Surgery (OPERAS): a prospective multicentre observational cohort study of opioid use after common surgical procedures

Not Applicable

Active, not recruiting

• Conditions: Opioid prescription and usage after undergoing a surgery; Anaesthesiology - Pain management; Surgery - Other surgery

• Registration Number: ACTRN12621001451897
• Lead Sponsor: Associate Professor Peter Pockney

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2021-10-25
• Last Update Posted: 9 October 2023

Recruitment & Eligibility

• Status: Active, not recruiting
• Sex: All
• Target Recruitment: 5000

Inclusion Criteria

Adult patients (greater than or including 18 years of age)
Acute or elective surgery
Operated on within the pre-specified study periods
Discharged to home/community/ usual residence
Undergoing any of the following surgeries:
General Surgery
- Cholecystectomy
- Appendicectomy
- Inguinal hernia repair
- Colon resection with or without stoma
- Sleeve gastrectomy

Orthopaedic Surgery
- Total shoulder arthroplasty/reverse shoulder arthroplasty
- Rotator cuff repair/labral repair
- ACL repair
- Hip arthroplasty
- Knee arthroplasty

Gynaecology
- Hysterectomy
- Oophorectomy and/or Salpingectomy

Urology
- Prostatectomy
- Cystectomy
- Nephrectomy

Exclusion Criteria

Paediatric patients (below 18 years of age)
On the opiate replacement programme (on methadone, suboxone, buprenorphine)
Patients discharged to hospice or with palliative intent
Patients discharged to rehabilitation (including inpatient rehabilitation service), nursing or supported care services, or another hospital, or not discharged should be excluded
Diagnostic procedures, e.g., endoscopy, diagnostic laparoscopy (without appendicectomy)
Multivisceral resections (defined as operations involving 2 or more distinct procedures of the gastrointestinal, hepatopancreatobiliary, genitourinary, or gynaecological systems e.g. hysterectomy with colorectal resection or any other operation where multiple eligible procedures are included) [to ensure the included standard procedures are internally consistent]
Each individual patient should only be included once in the OPERAS study. Return to theatre during the same admission is regarded as a complication and should not form a duplicate entry onto REDCap.

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Proportion and amount (morphine equivalent doses) of prescribed opiates - this will be determined by recording the opioids prescribed at discharge (based on discharge summaries, patient prescriptions and clinical records) and the same will be done by asking how many pills or mls of liquid opioids were consumed by patients. Doses from medications will be converted based on the ANZCA guidelines (ANZCA. PS01(PM) (Appendix). 2021.).<br>[ 7-days post-discharge]

Secondary Outcome Measures

Name	Time	Method
Quality of life via EQ5D-5L<br>[ 7-days post-discharge];Postoperative pain scale via the numeric rating scale[ 7-days post-discharge];Adequacy of pain relief prescribed via telephone questionnaire[ 7-days post-discharge];Requirement for further analgesia via telephone questionnaire [ 7-days post-discharge];Hospital readmissions for opiate-related side-effects or pain related to surgical pathology/procedure - collected via telephone questionnaire<br>[ 7-days post-discharge]