Manipulating NMDA-dependent learning to alter nocebo effects: A pharmacological fMRI study on pain and itch.
- Conditions
- ocebo effects (experimental model in healthy participants)Nocebo effectsInsufficiently explained pain and itch symptoms
- Registration Number
- NL-OMON49103
- Lead Sponsor
- niversiteit Leiden
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 100
To be eligible, participants must meet all of the following criteria:
1. Between 18 and 35 years of age
2. Good understanding of spoken and written English
3. Native Dutch speaker
A potential subject who meets any of the following exclusion criteria will be
excluded from participation in this study:
1. History of serious or chronic medical or psychiatric conditions
2. History of chronic pain or itch conditions
3. Experiencing pain or itch on the day of testing above the threshold of 1 out
of 10 on the NRS
4. Currently using antihistamines, analgesic medication, or itch-reducing
medication (in the 24 hours prior to testing)
5. Recent use of psychotropic drugs (including recreational drugs such as
cannabis and psychotropic prescription-medication; in the past month)
6. Currently being (or intending to become) pregnant, or currently breastfeeding
7. Colour-blindness
8. Body Mass Index under 16 or over 30
9. Meeting any exclusion criteria for entering the MR scanner (e.g., permanent
metal parts in the body)
10. Having a too high threshold for pain (where high pain cannot be induced
with temperatures lower than 49.5 °C) or not responding to histamine (no itch
response)
- A medical exam (carried out by a medical doctor) and a psychiatric screening
will be completed per participant prior to participation. A medical backup team
will be on call to further support the study medical doctor, who will monitor
participants at all times during the study.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The main study parameter is the magnitude of induced nocebo effects on<br /><br>self-reported pain and itch in the evocation phase as compared between the<br /><br>pharmacological groups. The magnitude of the induced nocebo effects on pain and<br /><br>itch is measured as the difference between self-reported pain or itch on a<br /><br>Numeric Rating Scales (NRS) between conditioned and control evocation trials,<br /><br>in early trials of the extinction phase.</p><br>
- Secondary Outcome Measures
Name Time Method