A Study Of Resilience And Mental Well-Being Through Breathing Practice For Clinical Care Professionals

Not Applicable

Recruiting

• Conditions: Burnout, Healthcare Workers; Breathing Exercises

• Registration Number: NCT07218458
• Lead Sponsor: Mayo Clinic

Brief Summary

The purpose of this study is to assess the immediate and long-term effects of structured breathing on clinical symptoms related to mental health including anxiety, depression, perceived stress, and sleep quality.

Detailed Description

Not available

Study Timeline

• Status Verified: 2025-10
• Study First Submitted: 2025-10-15
• Study First Submitted QC: 2025-10-16
• Last Update Submitted: 2025-10-16
• Study Start: 2025-10-20
• Study First Posted: 2025-10-20
• Last Update Posted: 2025-10-20
• Primary Completion: 2026-04-01
• Study Completion: 2026-06-01

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

• Participants must be healthcare professionals at the above-mentioned 4 MCHS sites (Eau Claire, La Crosse, Mankato, Albert Lea).
• Must score ≥40 on Copenhagen Burnout Inventory Q1-6.
• Participants must be physically fit enough to perform light exercise.
• Participants should read and understand English well enough to consent, complete measures, and follow instructions.
• Participants must have access to a smartphone or tablet.

Exclusion Criteria

• Active primary psychotic disorder or substance use disorder (except nicotine dependence) within the past year.
• Severe or unstable medical condition that could interfere with participation or data collection.
• Active neurological condition (including seizure disorder, traumatic brain injury, or stroke) that could affect cognitive functioning or brain imaging results.
• Chronic lung disease (e.g., COPD, cystic fibrosis) or aneurysm.
• Current pregnancy or planning to become pregnant during the study period

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Primary Outcome Measures

Name	Time	Method
Effects of Structured Breathing on Mental Health	From enrollment to end of treatment at 4 months	To assess the immediate and long-term effects of structured breathing on clinical symptoms related to mental health.; Changes and effects will be measured via questionnaire completion at baseline, 2 month, and 4 month intervals.; Overall mental health will be assessed based on an aggregate of results from Copenhagen Burnout Inventory (CBI), General Health Questionnaire (GHQ), Patient Health Questionnaire (PHQ-9), General Anxiety Disorder (GAD-7), Perceived Stress Scale, Professional Fulfillment Index (PFI), Linear Analog Self-Assessment (LASA), and Brief Resilience Scale (BRS).
Effects of Structured Breathing on Sleep Quality	From enrollment to the end of treatment at 4 months	To assess the immediate and long-term effects of structured breathing on clinical symptoms related to sleep quality.; This outcome will be measured via questionnaire completion at baseline, 2 month, and 4 month intervals. Questionnaires include Pittsburgh Sleep Quality Index (PSQI) and Modified Fatigue Impact Scale (MFIS).

Secondary Outcome Measures

Name	Time	Method
Structured Breathing Effects on Cerebral Circulation	From enrollment to the end of treatment at 4 months	To evaluate the immediate and long-term effects of structured breathing on local tissue oxygen delivery and cerebral circulation in breathing training group.; These effects will be measured utilizing fNIRS (functional near-infrared spectroscopy) technology, which measures changes in oxygenated blood. Pre-and-post intervention fNIRS testing will demonstrate how structured breathing influences cerebral circulation and oxygenation in the brain.

Trial Locations

Locations (4)

Mayo Clinic Health System-Albert Lea; 🇺🇸 Albert Lea, Minnesota, United States

Mayo Clinic Health System-Mankato; 🇺🇸 Mankato, Minnesota, United States

Mayo Clinic Health System-Eau Claire Clinic; 🇺🇸 Eau Claire, Wisconsin, United States

Mayo Clinic Health System-La Crosse; 🇺🇸 La Crosse, Wisconsin, United States