Maintaining Remission of Ulcerative Colitis with Faecal Microbiota Transplantation: the MR-UC-FMT Trial

Not Applicable

• Conditions: lcerative Colitis; Inflammatory Bowel Disease; Oral and Gastrointestinal - Inflammatory bowel disease; Ulcerative Colitis; Inflammatory and Immune System - Autoimmune diseases

• Registration Number: ACTRN12622001434785
• Lead Sponsor: Central Adelaide Local Health Network

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Completion: 2021-02-04
• Study Start: 2022-11-08
• Last Update Posted: 14 November 2022

Recruitment & Eligibility

• Status: Stopped early
• Sex: All
• Target Recruitment: 36

Inclusion Criteria

Patients aged 18 - 75 years
Formal diagnosis of UC for greater than or equal to 1 month
Currently under the care of a gastroenterologist
Mild to Moderately Active UC with Total Mayo score 3 to 10 inclusive.
Mayo Endoscopic Sub Score greater than or equal to 2 (to ensure symptoms are due to UC and not due to a concurrent functional bowel disorder)

Exclusion Criteria

Severe UC with Total Mayo score of greater than or equal to 11 or by Truelove Witts Criteria
Diminished mental capacity preventing consent
Pregnancy
Surgical resection of any part of the intestine
Anticoagulation or dual antiplatelet use
Antibiotic use at time of enrolment
Contraindications to the use of prednisolone (e.g. poorly controlled Diabetes Mellitus, history of steroid-induced mental health complications such as depression, mania or psychosis)
Plans for travel from South Australia for >4 weeks during the 12 months study period

Study & Design

• Study Type: Interventional
• Study Design: Not specified