Paediatric and Adult Causes of Encephalitis and Meningitis: The PACEM study.

Completed

• Conditions: brain-infection; meningo-encephalitis; 10019815; 10007951

• Registration Number: NL-OMON35777
• Lead Sponsor: Academisch Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 6 May 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 200

Inclusion Criteria

Patients of all ages (including premature born infants) with a clinical suspicion of meningitis or encephalitis of whom central spine fluid is obtained, are eligible for inclusion in this study.

Exclusion Criteria

- neurosurgical operation in recent past (last 3 months)
- drain with connection to cerebrospinal fluid

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>1. Detection of viruses and other micro-organisms in CSF, blood, nasopharyngeal<br /><br>aspirates and feces<br /><br>2. Clinical signs and symptoms as defined as: headache, fever, irritability,<br /><br>altered consciousness, seizures, etc in relation to cause<br /><br>3. Cell count, protein and glucose level of CSF and relation with causative<br /><br>organism<br /><br>4. Death or permanent sequellae due to meningitis/encephalitis</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>1. Costs, duration of hospitalization and antibiotic use due to<br /><br>meningitis/encephalitis</p><br>