Fat Absorption and Metabolism After Roux-en-Y Gastric Bypass

Not Applicable

Completed

• Conditions: Bariatric Surgery
• Interventions: Other: Metabolic test; Other: DXA-scan; Other: MRS; Other: Feces collection

• Registration Number: NCT04859816
• Lead Sponsor: Hvidovre University Hospital

Brief Summary

Using intravenous and oral administration of stable isotope tracers, we will investigate the importance of altered fat absorption and altered whole body fat metabolism for the reduced postprandial systemic TAG concentrations in non-diabetic patients in weight stable phase after RYGB.

Detailed Description

Not available

Study Timeline

• Study Start: 2021-04-01
• Study First Submitted: 2021-04-12
• Study First Submitted QC: 2021-04-21
• Study First Posted: 2021-04-26
• Primary Completion: 2022-05-01
• Study Completion: 2022-05-01
• Status Verified: 2022-08
• Last Update Submitted: 2022-08-20
• Last Update Posted: 2022-08-23

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 24

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Roux-en-Y gastric bypass operated participants	Feces collection	Roux-en-Y gastric bypass operated participants in weight stable phase \> 1 year from surgery
Control participants	Feces collection	Age, sex, and BMI-matched un-operated participants.
Roux-en-Y gastric bypass operated participants	Metabolic test	Roux-en-Y gastric bypass operated participants in weight stable phase \> 1 year from surgery
Roux-en-Y gastric bypass operated participants	DXA-scan	Roux-en-Y gastric bypass operated participants in weight stable phase \> 1 year from surgery
Roux-en-Y gastric bypass operated participants	MRS	Roux-en-Y gastric bypass operated participants in weight stable phase \> 1 year from surgery
Control participants	Metabolic test	Age, sex, and BMI-matched un-operated participants.
Control participants	MRS	Age, sex, and BMI-matched un-operated participants.
Control participants	DXA-scan	Age, sex, and BMI-matched un-operated participants.

Primary Outcome Measures

Name	Time	Method
Area under the curve of plasma triacylglycerol	6 hours	During a high-fat liquid mixed meal test

Secondary Outcome Measures

Name	Time	Method
Recovery of oral stable triacylglycerol isotope tracer in feces	4 days	An oral stable triacylglycerol isotope tracer will be administered during a high-fat liquid mixed meal test. Feces will be collected the following 4 days to determine the recovery of the tracer in feces.

Trial Locations

Locations (1)

Hvidovre Hospital; 🇩🇰 Hvidovre, Denmark