PROlonged versus Single dose in PEnicillin oral Challenge Testing

Not Applicable

Recruiting

• Conditions: Allergies; Adverse drug reaction; Penicillin allergy; Delayed hypersensitivity; Inflammatory and Immune System - Allergies

• Registration Number: ACTRN12623001242617
• Lead Sponsor: Austin Health

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2023-11-30
• Last Update Posted: 22 January 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 120

Inclusion Criteria

1. Adult patients referred to the outpatient allergy clinic or inpatient allergy service for a penicillin allergy history (i.e. amoxicillin or penicillin unspecified)

2. Adult patients with an immune-mediated penicillin allergy history with either delayed phenotype (> 2 hours post dose) or unknown timing

3. Tolerated first dose of an oral penicillin challenge

4. Being challenged to the implicated penicillin. In setting of unknown penicillin, challenge either to penicillin VK or amoxicillin

5. Willing and able to give consent

6. Willing and able to undergo telehealth or in clinic review post challenge

Exclusion Criteria

1. Patient age is < 18 years;

2. Any other illness that, in the investigator’s judgement, will substantially increase the risk associated with subject’s participation in this study

3. Stevens-Johnson Syndrome or Toxic Epidermal Necrolysis to beta-lactam

4. Inpatients receiving concurrent beta-lactam antibiotic therapy

Study & Design

• Study Type: Interventional
• Study Design: Not specified