Freezing of gait in Parkinson's disease: in search of the underlying mechanism and the application of a new treatment option - Freezing of gait in Parkinson's disease
- Conditions
- Parkinson's disease, in particular the symptom Freezing of Gait
- Registration Number
- EUCTR2009-012643-42-NL
- Lead Sponsor
- niversity Medical Center Groningen
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Authorised-recruitment may be ongoing or finished
- Sex
- All
- Target Recruitment
- Not specified
Parkinson's disease according to the criteria of the UK brain bank criteria.
Are the trial subjects under 18? no
Number of subjects for this age range:
F.1.2 Adults (18-64 years) yes
F.1.2.1 Number of subjects for this age range
F.1.3 Elderly (>=65 years) yes
F.1.3.1 Number of subjects for this age range
- Presence of neurological central nervous system disorders other than idiopathic Parkinson's disease
- Surgical treatment for idiopathic Parkinson's disease, such as deep brain stimulation
- Dementia (i.e. a score below the cut-off of the Mattis Dementia Rating Scale)
- Other significant co-morbidity
- Contraindications to MRI scanning:
* metal objects in or near the body, such as a pacemaker, insuline pump, prothesis and/or metal splinters in eye.
* tattoos and/or piercings
* claustrophobia
- Controindications to the use of methylphenidate:
* cardiovascular disease, including moderate to severe hypertension
* structural cardiac abnormalities
* cardiomyopathy
* advanced arteriosclerosis
* hyperexcitability
* renal impairment
* porphyria
* bipolar disorder
* unstable personality
* anxiety disorder
* history of suicide attempts
* gilles de la tourette syndrome
* thyriod disease
* glaucoma
* pregnancy
* use of MAO-inhibitors
* use of vasopressors
Study & Design
- Study Type
- Interventional clinical trial of medicinal product
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method