Waarom blokkeren sommige Parkinson patiënten tijdens het lopen?
- Conditions
- Parkinson's disease with and without Freezing of Gait, healthy controls.
- Registration Number
- NL-OMON23006
- Lead Sponsor
- niversity Medical Center GroningenUniversity of Groningen
- Brief Summary
/A
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 80
Inclusion Criteria
Parkinson's disease according to the UK brain bank criteria.
Exclusion Criteria
1. Presence of neurological central nervous system disorders other that idiopathic PD;
2. Surgical treatment for idiopathic PD, such as deep brain stimulation;
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method First primary outcome: Performance of Parkinson's disease patients with Freezing of Gait on behavioral tasks compared to Parkinson's disease patients without Frezzing of Gait and healthy controls. <br><br /><br /><br>Second primary outcome: Cerebral activation patterns during shifting between response sets in Parkinson's disease patients with Freezing of Gaot, relative to Parkinson's disease patients without Freezing of Gait and healthy controls. <br><br /><br /><br>Third primary outcome: Change of performance on response shifting task and gait trajectory after administration of Methylphenidate in Parkinson's disease patients with Freezing of Gait, relative to placebo. <br><br /><br /><br>Fourth primary outcome: Cerebral activation change after administration of Methylphenidate in Parkinson's disease patients with Freezing of Gait, relative to placebo. <br>
- Secondary Outcome Measures
Name Time Method First secondary outcome is the performance on the motor tasks of all groups, compared to the performance on the cognitive task and dual task, by comparing the number of correct responses.<br><br /><br /><br>Second secondary outcome is the cerebral activation pattern during shifting between motor task compared to the cerebral activation patterns during shifting between cognitive tasks and during dual tasks in all groups.<br>