ADMA and renal endothelial dysfunctio
- Conditions
- hypertensionmild renal insufficiencyADMAhypertensiemilde nierfunctiestoornsisenADMA
- Registration Number
- NL-OMON20074
- Lead Sponsor
- Dr. A.A. KroonP. Debyelaan 25, P.O. Box 58006202 AZ MaastrichtPhone: +31 43 387 7005 (secretary
- Brief Summary
/A
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 45
Inclusion Criteria
1. Hypertension
(Office blood pressure: >140 and/or >90 mmHg or mean ABPM blood pressure: >125 and/or >80 mmHg)
Exclusion Criteria
1. Primary kidney diseases or urological
complaints
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method o Basal renal perfusion measured <br /> <br>o Fractional change in renal perfusion after <br> intrarenal L-NMMA infusion<br /><br>o Arterial en venous ADMA, SDMA<br> (symmetric dimethylarginine) and <br> L-arginine concentrations<br /><br>o Renal elimination of systemic ADMA,<br> SDMA and L-arginine<br>
- Secondary Outcome Measures
Name Time Method o Microalbuminuria (24-hour urine<br> collection)<br /><br>o Creatinin clearance (24-hour urine<br> collection)<br /><br>o Blood pressure<br /><br>o Plasma LDL (low density lipoproteins), <br> HDL (high density lipoproteins),<br> triglycerides and total cholesterol<br> concentrations<br>