Study on the Mechanism of Endotoxic Acute Lung Injury-induced Golgi Stress Based on Regulating HO-1/CREB3
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 150
- 试验地点
- 1
- 主要终点
- cAMP-response element binding protein 3, CREB3
研究概览
简要总结
This study was an ambispective observational cohort study that included sepsis patients hospitalized in the Intensive care unit (ICU) of the Nankai Hospital. All patients met the consensus criteria of sepsis-3. The purpose of this study is to investigate the valuable biomarkers for the severity of sepsis and predictors of 30-day mortality for patients with sepsis.
详细描述
All patients met the consensus criteria of sepsis-3. The purpose of this study is to investigate the valuable biomarkers for the severity of sepsis and predictors of 30-day mortality for patients with sepsis.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Other
入排标准
- 年龄范围
- 18 Years 至 100 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Males or females over the age of 18;
- •Sepsis was diagnosed within 48h which meets SPESIS 3 criteria;
- •Capable of understanding the purpose and risk of the study;
- •Patients or proxy must give written informed consent before any assessment is performed.
排除标准
- •Pregnancy, lactation or perinatal period;
- •Breast carcinoma;
- •HIV seropositive or Syphilis seropositive;
- •Any clinical-relevant condition that might affect study participation and/or study results;
- •Participation in any other intervention trial;
- •Unwillingness or inability to following the study protocol in the investigators opinion.
结局指标
主要结局
cAMP-response element binding protein 3, CREB3
时间窗: Up to Day 28
CREB3 levels were measured in the PBMCs of sepsis patients and healthy controls
ADP-ribosylation factor 4, ARF4
时间窗: Up to Day 28
ARF4 levels were measured in the PBMCs of sepsis patients and healthy controls
次要结局
- Heme oxygnase-1, HO-1(Up to Day 28)
- Oxygenation index(Up to Day 28)
- Mechanical ventilation days(Up to Day 28)
- Sequential Organ-Failure Assessment (SOFA) score(Up to Day 28)
- ARF family(Up to Day 28)
- Inflammation biomarkers Inflammation levels(Up to Day 28)
- ICU stay length(Up to Day 90)
- 28 days survive(Up to Day 28)
- Acute Physiology and Chronic Health Evaluation II (APACHE II) score(Up to Day 28)
研究者
Jianbo Yu
Prof.
Tianjin Nankai Hospital