eural correlates of trauma-focused psychotherapy in PTSD: A longitudinal fMRI investigatio

Recruiting

Conditions: Post-traumatic stress disorder
psychological trauma
PTSD
10013465

Registration Number: NL-OMON48147

Lead Sponsor: Rijksuniversiteit Groningen

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: Not specified

Target Recruitment: 60

Inclusion Criteria

1. Participants must be full of age (18 years or older).
2. Meet the criteria for post-traumatic stress disorder (PTSD).
3. Must be enrolled in trauma-focused psychotherapy (TFT).
4. Participants must be capable of giving consent.

Exclusion Criteria

1. Presence of metallic devices, e.g. metal implants or cardiac pacemaker
2. Meet diagnostic criteria for
a. Pain disorder
b. Bipolar disorder
c. Dissociative Identity Disorder
d. Schizophrenia
e. Neurological disorders
3. Alcohol or drug abuse in the last 6 months
4. Suspected pregnancy
5. Claustrophobia
6. Refusal that general practitioner will be informed when structural brain
abnormalities could be detected during experiment

Study & Design

Study Type: Observational invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The main study parameters are differences in BOLD activation patterns between<br /><br>responders vs. non-responders following the fMRI paradigms. A treatment<br /><br>responder analysis will be conducted to identify (1) pre-post changes in brain<br /><br>activation responding to a script-driven trauma confrontation protocol and<br /><br>emotion reactivity task and (2) pre-therapy activation which could predict<br /><br>treatment outcome. Functional imaging data will be analyzed with<br /><br>region-of-interest and whole-brain exploratory analysis. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Secondary parameters include 1) the psychophysiological reactivity elicited<br /><br>during the functional imaging paradigms (script driven imagery and emotion<br /><br>reactivity), 2) resting-state functional imaging data for connectivity<br /><br>analyses, and 3) patient characteristics to describe the patients and<br /><br>characterize possible subgroups of patients (those who will and those who will<br /><br>not benefit from treatment). </p><br>