eural correlates of psychotherapy in posttraumatic stress disorder related to child maltreatment

Phase 4

Recruiting

Conditions: F43.1
Posttraumatic stress disorder (DSM-5) after abuse/maltreatment in childhood/adolescenceHealthy volunteers
Post-traumatic stress disorder

Registration Number: DRKS00021269

Lead Sponsor: Justus-Liebig-Universität Gießen

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: All

Target Recruitment: 145

Inclusion Criteria

Patients with PTSD-CM: Adults with posttraumatic stress disorder (PTSD) following child maltreatment, which had been inflicted upon them by a caregiver or authority figure before the age of 18.
Ongoing stable medication since 3 months is allowed.

Healthy controls: adults with experience of an equivalent trauma during childhood or youth, but without PTSD-diagnosis or any other mental disorder; as well as adults without trauma experience and without any psychological disorder.

Exclusion Criteria

PTSD-CM patients:
psychotic disorders, suicidality, ongoing maltreatment, acute substance abuse disorder, borderline personality disorder, dissociative identity disorder, organic brain disease, serious physical illness, current psychotherapeutic treatment, current psychopharmacological medication < 3 months stable, standard MRI-exclusion criteria;

Healthy controls:
any psychological disorder, current psychotherapeutic or psychiatric treatment, serious physical illness, standard MRI exclusion criteria

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Time of measurement: pre, post and follow up (follow up without waitlist control group);<br><br>Experimental research question (MRI): Blood oxygen level dependent (BOLD) response in amygdala, insula, hippocampus, ACC, PFC;<br><br>Brain structural research question: grey matter volume (hippocampus, amygdala, PFC, ACC); fractional anisotrophy (corpus callosum, uncinate fasciculus, cingulum, superior longitudinal fasciculus);<br><br>Pattern seperation task (stimulus discrimination): pattern seperation index

Secondary Outcome Measures

Name	Time	Method
Time of Measurement: pre, post and follow-up (follow up without waitinglist control group):<br><br>Reaction times und affect ratings; explorative whole brain analysis; skin conductance response<br><br>