Reduction in interleukin-5 and other eosinophil biomarkers by full-house endoscopic sinus surgery in the treatment of severe nasal polyps
- Conditions
- Chronic rhinosinusitisNasal polypChronic rhinosinusitisNasal polypCRSwNPEosinophilEosinophilicEosinophiliainterleukinLJIL-
- Registration Number
- TCTR20200530002
- Lead Sponsor
- Department of Otolaryngology, Faculty of medicine, Chulalongkorn University
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending (Not yet recruiting)
- Sex
- All
- Target Recruitment
- 20
Any CRSwNP patient is defined as the presence of two or more symptoms for > 12 weeks, one of which should be:
either nasal blockage/obstruction/congestion or nasal discharge (anterior/posterior nasal drip)
± facial pain/pressure
± reduction or loss of smell
AND along with endoscopic and radiographic evidence of nasal polyps, grade ≥2 and diffuse bilateral mucosal inflammation
AND have indication for sinus surgery
**grade 0 being no visible polyps; grade 1 being polyps confined to the middle meatus; grade 2 being polyps beyond the middle meatus but not completely obstructing the nasal cavity; and grade 3 being polyps completely obstructing the nasal cavity
1. prior sinus surgery
2. unilateral sinus changes
3. sinus disease associated with systemic conditions
4. under the age of 18
5. pregnant women
6. undertaking systemic and intranasal steroids and immunosuppressive medication during the past month
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Effects on interleukin-5, soluble IL-5Rα nasal and serum level reduction by endoscopic sinus surger 4 weeks Measure these biomarker at baseline and 4 weeks time point
- Secondary Outcome Measures
Name Time Method Effects on eosinophil byproducts nasal and serum level reduction by endoscopic sinus surgery 4 weeks Measure nasal and serum level of ECP, eotaxin and serum eosinophil at baseline and 4 weeks timepoint