Investigating the Effects of Krill Oil and Krill Protein on Post-exercise Muscle Protein Metabolism: a Randomised Controlled Trial
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 48
- 试验地点
- 1
- 主要终点
- Post-exercise muscle protein synthesis
研究概览
简要总结
The aim of the current study is to find out if krill oil can increase muscle building processes in response to resistance (weightlifting) type exercise. Others aim are to determine the effects of krill protein, and the interaction of krill oil and protein, on muscle building processes in response to resistance (weightlifting) type exercise.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
盲法说明
All supplements with be colour and flavour matched
入排标准
- 年龄范围
- 60 Years 至 90 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Be 60 years old or older
- •Have a BMI of less than 35kg/m2
- •Be participating in structured exercise for less than 2h per week
排除标准
- •Severe cardiovascular disease
- •Seizure disorders,
- •Uncontrolled hypertension (>150/90mmHg at baseline measurement)
- •Cancer or cancer that has been in remission <5 years
- •Ambulatory impairments which would limit ability to perform assessments of muscle function
- •Taking medication known to affect muscle (e.g., steroids)
- •Have an implanted electronic device (e.g., pacemaker/defibrillator/insulin pump),
- •Anticoagulant therapy
- •Allergies to seafood
- •Regular consumption of more than 1 portion of oily fish per week.
研究组 & 干预措施
Vegetable oil + Carbohydrate
The vegetable oil will be a placebo control for the Krill oil (4g/day). The carbohydrate will be a placebo control for the Krill protein (20g)
干预措施: Vegetable oil (Dietary Supplement)
Vegetable oil + Carbohydrate
The vegetable oil will be a placebo control for the Krill oil (4g/day). The carbohydrate will be a placebo control for the Krill protein (20g)
干预措施: Carbohydrate (Dietary Supplement)
Vegetable oil + Krill protein
The vegetable oil will be a placebo control for the Krill oil (4g/day). Krill protein will be our active intervention (20g)
干预措施: Krill protein (Dietary Supplement)
Vegetable oil + Krill protein
The vegetable oil will be a placebo control for the Krill oil (4g/day). Krill protein will be our active intervention (20g)
干预措施: Vegetable oil (Dietary Supplement)
Krill oil + Carbohydrate
The Krill oil will be the active supplement for the intervention (4g/day). The carbohydrate will be a placebo control for the Krill protein (20g)
干预措施: Carbohydrate (Dietary Supplement)
Krill oil + Carbohydrate
The Krill oil will be the active supplement for the intervention (4g/day). The carbohydrate will be a placebo control for the Krill protein (20g)
干预措施: Krill oil (Dietary Supplement)
Krill oil + Krill protein
Both the Krill oil (4g/day) and the Krill protein will be the active intervention supplements (20g)
干预措施: Krill protein (Dietary Supplement)
Krill oil + Krill protein
Both the Krill oil (4g/day) and the Krill protein will be the active intervention supplements (20g)
干预措施: Krill oil (Dietary Supplement)
结局指标
主要结局
Post-exercise muscle protein synthesis
时间窗: 3-7 hours
Muscle protein synthesis measured 3-7h after a single bout of resistance exercise
次要结局
- Change in balance(Change from baseline to 8 weeks)
- Change in gait speed(Change from baseline to 8 weeks)
- Basal muscle protein synthesis(0-3 hours)
- Change in Muscle thickness(Change from baseline to 8 weeks)
- Change in grip strength(Change from baseline to 8 weeks)
- Change in fat mass(Change from baseline to 8 weeks)
- Change in muscle strength(Change from baseline to 8 weeks)
- Change in lean mass(Change from baseline to 8 weeks)
- Change in Chair rise time(Change from baseline to 8 weeks)
- Change in Erythrocyte fatty acid profile(Change from baseline to 8 weeks)
研究者
Stuart Gray
Professor
University of Glasgow