NCT04048096CompletedNot Applicable
Effects of Krill Oil Supplementation on Muscle Function in Older Adults
Conditions
Interventions
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- University of Glasgow
- Enrollment
- 102
- Locations
- 1
- Primary Endpoint
- Change in Muscle strength
Study Overview
Brief Summary
The aim of this study is to determine the effects of krill oil supplementation on muscle mass in function in older adults. Half of the participants will receive krill oil supplements and the other half a placebo.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Treatment
- Masking
- Triple (Participant, Investigator, Outcomes Assessor)
Eligibility Criteria
- Ages
- 65 Years to — (Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •BMI less than 35kg/m2
Exclusion Criteria
- •severe cardiovascular disease
- •seizure disorders
- •uncontrolled hypertension (>150/90mmHg at baseline measurement)
- •cancer or cancer that has been in remission <5 years
- •ambulatory impairments which would limit ability to perform assessments of muscle function
- •taking medication known to affect muscle (e.g. steroids)
- •have an implanted electronic device (e.g. pacemaker/defibrillator/insulin pump)
- •on anticoagulant therapy
- •allergies to seafood
- •regular consumption of more than 2 portions of oily fish per week.
Arms & Interventions
Placebo
Placebo Comparator
4g/day of mixed vegetable oil supplements
Intervention: Placebo (Dietary Supplement)
Krill
Experimental
4g/day krill oil
Intervention: Krill Oil (Dietary Supplement)
Outcomes
Primary Outcomes
Change in Muscle strength
Time Frame: Change from baseline to 6 months
knee extensor muscle strength
Secondary Outcomes
- Change in Body Fat(Change from baseline to 6 months)
- Change in Lean Mass(Change from baseline to 6 months)
- Change in Grip strength(Change from baseline to 6 months)
- Change in Fasting glucose(Change from baseline to 6 months)
- Change in CRP(Change from baseline to 6 months)
- Change in Muscle thickness(Change from baseline to 6 months)
- Change in Short performance physical battery test(Change from baseline to 6 months)
- Change in Blood lipids(Change from baseline to 6 months)
- Change in Erythrocyte fatty acid profile(Change from baseline to 6 months)
Investigators
Stuart Gray
Senior Lecturer in Exercise and Metabolic Health
University of Glasgow
Study Sites (1)
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