Uncovering the Mechanisms Through Which Krill Oil Increases Muscle Function in Older Adults.
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 80
- 试验地点
- 1
- 主要终点
- Grip strength
研究概览
简要总结
This study aims to determine the mechanisms via which krill oil supplementation increases muscle strength and whether this translates to improvements in gait and functional characteristics in older adults. The studies we will carry out will establish, in healthy older adults, the effects of 6 months of supplementation with krill oil
Objective 1) Muscle structure and function Hypothesis: Krill oil supplementation will increase muscle size and strength alongside positive changes in muscle architecture (pennation angle and fascicle length).
Objective 2) Neuromuscular control and central nervous system (CNS) function Hypothesis: Krill oil supplementation will improve Neuromuscular Junction (NMJ) transmission stability and increase central drive and intramuscular coherence, as a measure of muscle synergy.
Objective 3) Gait and functional characteristics Hypothesis: Krill oil supplementation will improve gait and functional characteristics.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
盲法说明
All supplements will be matched for taste and look
入排标准
- 年龄范围
- 65 Years 至 90 Years（Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •* body mass index (BMI) \/= 65 years
- •* Capacity to consent
- •* Living within the Glasgow area
排除标准
- •Diabetes mellitus
- •Severe cardiovascular disease
- •Seizure disorders
- •Uncontrolled hypertension (>150/90mmHg)
- •Active cancer or cancer that has been in remission <5 years
- •Participation in any resistance exercise training within the last 6 months
- •Impairments which may limit ability to perform assessments of muscle function
- •Fish/shellfish allergy
- •Taking medication known to affect muscle (e.g. steroids, Selective serotonin reuptake inhibitors) or anticoagulants (e.g. warfarin)
- •Taking omega-3 supplements in the last 3 months
- •Regularly consuming 1 or more portions of oily fish per week
- •Not able to understand English
研究组 & 干预措施
Vegetable oil
4g/day vegetable oil for 24 weeks
干预措施: Vegetable oil (Dietary Supplement)
Krill oil
4/g/day krill oil for 24 weeks
干预措施: Krill oil (Dietary Supplement)
结局指标
主要结局
Grip strength
时间窗: Change from baseline to 24 weeks
We will measure grip strength using a handgrip dynamometer, making 3 maximal contractions in each hand, with the dominant hand recorded. The highest grip strength will be used in analysis.
Neuromuscular junction transmission instability
时间窗: Change from baseline to 24 weeks
We will assess peripheral motor unit (MU) characteristics in the vastus lateralis muscle using intramuscular electromyography
Gait speed
时间窗: Change from baseline to 24 weeks
We will measure gait speed using a gaitrite connected mat during a 4 m walk test and the timed up and go test at usual speed.
次要结局
- Erythrocyte fatty acid composition(Change from baseline to 24 weeks)
- Knee extensor force steadiness(Change from baseline to 24 weeks)
- Gait cycle with leg support parameters(Change from baseline to 24 weeks)
- Hand flexor muscles intermuscular coherence(Change from baseline to 24 weeks)
- Cortico-muscular coherence between sensory motor cortex and hand extensor muscles(Change from baseline to 24 weeks)
- Femoral Nerve Stimulation(Change from baseline to 24 weeks)
- TMS Inhibition(Change from baseline to 24 weeks)
- Vastus lateralis fascicle length(Change from baseline to 24 weeks)
- Vastus lateralis motor unit conduction velocity(Change from baseline to 24 weeks)
- Vastus lateralis and vastus medialis intramuscular coherence(Change from baseline to 24 weeks)
- Knee extensor maximal torque(Change from baseline to 24 weeks)
- Vastus lateralis muscle cross sectional area(Change from baseline to 24 weeks)
- Vastus lateralis pennation angle(Change from baseline to 24 weeks)
- Transcranial Magnetic Stimulation (TMS)(Change from baseline to 24 weeks)
- TMS Excitation(Change from baseline to 24 weeks)
- Gait characteristics during 4m walk test and the timed up and go test(Change from baseline to 24 weeks)
研究者
Stuart Gray
Professor of Muscle and Metabolic Health
University of Glasgow