Investigating the Effects of Krill Oil and Krill Protein on Post-exercise Muscle Protein Metabolism

Not Applicable

Recruiting

• Conditions: Hypertrophy

• Registration Number: NCT05774444
• Lead Sponsor: University of Glasgow

Brief Summary

The aim of the current study is to find out if krill oil can increase muscle building processes in response to resistance (weightlifting) type exercise. Others aim are to determine the effects of krill protein, and the interaction of krill oil and protein, on muscle building processes in response to resistance (weightlifting) type exercise.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2023-03-07
• Study First Submitted QC: 2023-03-07
• Study First Posted: 2023-03-17
• Study Start: 2023-05-01
• Status Verified: 2025-03
• Last Update Submitted: 2025-03-25
• Last Update Posted: 2025-03-30
• Primary Completion: 2025-05-25
• Study Completion: 2025-05-25

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 48

Inclusion Criteria

• Be 60 years old or older
• Have a BMI of less than 35kg/m2
• Be participating in structured exercise for less than 2h per week

Exclusion Criteria

• Diabetes
• Severe cardiovascular disease
• Seizure disorders,
• Uncontrolled hypertension (>150/90mmHg at baseline measurement)
• Cancer or cancer that has been in remission <5 years
• Ambulatory impairments which would limit ability to perform assessments of muscle function
• Dementia
• Taking medication known to affect muscle (e.g., steroids)
• Have an implanted electronic device (e.g., pacemaker/defibrillator/insulin pump),
• Anticoagulant therapy
• Allergies to seafood
• Regular consumption of more than 1 portion of oily fish per week.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Post-exercise muscle protein synthesis	3-7 hours	Muscle protein synthesis measured 3-7h after a single bout of resistance exercise

Secondary Outcome Measures

Name	Time	Method
Change in Muscle thickness	Change from baseline to 8 weeks	Vastus lateralis muscle thickness measured by ultrasound
Change in grip strength	Change from baseline to 8 weeks	Grip strength measured with a Jamar dynamometer
Change in fat mass	Change from baseline to 8 weeks	Whole body fat mass measured by BIA
Change in muscle strength	Change from baseline to 8 weeks	Knee extensor muscle strength measured isometrically
Change in lean mass	Change from baseline to 8 weeks	Whole body lean mass measured by BIA
Change in Chair rise time	Change from baseline to 8 weeks	Time taken to get up and down from a chair 5 times
Change in Erythrocyte fatty acid profile	Change from baseline to 8 weeks	Erythrocyte fatty acid profile
Change in balance	Change from baseline to 8 weeks	Ability to stand for 10 seconds in full tandem, semi-tandem and feet together
Change in gait speed	Change from baseline to 8 weeks	Time taken to walk 4 metres at a normal walking pace
Basal muscle protein synthesis	0-3 hours	Muscle protein synthesis measured from 0-3h after an overnight fast

Trial Locations

Locations (1)

Stuart Robert Gray; 🇬🇧 Glasgow, United Kingdom