Health Benefits of a 21-day Daniel Fast

Not Applicable

Completed

• Conditions: Effects of Krill Oil on Human Health
• Interventions: Dietary Supplement: Krill oil supplementation

• Registration Number: NCT01378767
• Lead Sponsor: University of Memphis

Brief Summary

The investigators hypothesized that individuals supplementing with krill oil capsules (two grams per day) would experience enhanced improvements in health-related variables during a 21-day Daniel Fast.

Detailed Description

One of the main purposes of the this investigation was to determine if krill oil supplementation (two grams per day for 21 days) enhances the effects of a 21-day Daniel Fast, particularly in regards to blood lipids and lipid peroxidation. The investigators were also interested in determining if adiponectin and/or resistin change in response to the fast, as these adipokines could potentially mediate the favorable glucoregulatory changes the investigators observed in our initial investigation of a 21-day Daniel Fast. Finally, the investigators sought to determine the changes in macronutrient and micronutrient intake during a Daniel Fast, and how these dietary changes affect our selected hemodynamic, anthropometric, blood lipid, glucoregulatory, oxidative stress, inflammatory, renal, and hepatic biomarkers.

Study Timeline

• Study Start: 2010-09
• Primary Completion: 2010-12
• Study Completion: 2010-12
• Status Verified: 2011-06
• Study First Submitted: 2011-06-10
• Study First Submitted QC: 2011-06-20
• Last Update Submitted: 2011-06-20
• Study First Posted: 2011-06-22
• Last Update Posted: 2011-06-22

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 39

Inclusion Criteria

• Must be 18 years of age or older.
• Must be willing to partake in a vegan diet for 21 days.
• Must be willing to consume either krill oil or coconut oil capsules (assigned randomly).

Exclusion Criteria

• Smokers
• regular consumption of antioxidant supplements
• women who were pregnant or seeking to become pregnant
• poor veins (veins that made it difficult to successfully obtain a blood draw - this was determined via a visual inspection)

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Krill oil capsules	Krill oil supplementation	Two grams per day daily for 21 days
Coconut oil capsules	Krill oil supplementation	Two grams per day for 21 days

Primary Outcome Measures

Name	Time	Method
Blood Lipids	Change from baseline at 3 weeks	Total Cholesterol, LDL-C, HDL-C, VLDL-C, Triglyerides
Glucoregulatory markers	Change from baseline at 3 weeks	Blood glucose, blood insulin, Serum resistin, serum adiponectin
Markers of Oxidative Stress and Antioxidant Status	Change from baseline at 3 weeks	Plasma malondialdehyde, plasma hydrogen peroxide, plasma nitrate/nitrite, Trolox Equivalent Antioxidant Capacity (measured in serum)
Blood Pressure	Change from baseline at 3 weeks	Systolic blood pressure, diastolic blood pressure
C-reactive protein	Change from baseline at 3 weeks

Secondary Outcome Measures

Name	Time	Method
Anthropometric Variables	Change from baseline at 3 weeks	bodyweight, body mass index, waist circumference, hip circumference, body fat percentage, fat mass, fat free mass
Metabolic Panel	Change from baseline at 3 weeks	Blood urea nitrogen, creatinine, sodium, potassium, carbon dioxide, calcium, protein, albumin, globulin, bilirubin, alkaline phosphatase, aspartate transaminase, alanine transaminase
Complete Blood Count	Change from baseline at 3 weeks	White blood cells, red blood cells, hemoglobin, hematocrit, mean cell volume, mean cell hemoglobin, mean corpuscular hemoglobin concentration, red blood cell distribution width, platelets, neutrophils, lymphocytes, monocytes, eosinophils, basophils

Trial Locations

Locations (1)

Cardiorespiratory/Metabolic Laboratory; 🇺🇸 Memphis, Tennessee, United States