Biochemical, Hemodynamic, and Anthropometric Effects of a 21-day Daniel Fast in Men and Women
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 39
- 试验地点
- 2
- 主要终点
- Blood Lipids
研究概览
简要总结
The investigators hypothesized that individuals supplementing with krill oil capsules (two grams per day) would experience enhanced improvements in health-related variables during a 21-day Daniel Fast.
详细描述
One of the main purposes of the this investigation was to determine if krill oil supplementation (two grams per day for 21 days) enhances the effects of a 21-day Daniel Fast, particularly in regards to blood lipids and lipid peroxidation. The investigators were also interested in determining if adiponectin and/or resistin change in response to the fast, as these adipokines could potentially mediate the favorable glucoregulatory changes the investigators observed in our initial investigation of a 21-day Daniel Fast. Finally, the investigators sought to determine the changes in macronutrient and micronutrient intake during a Daniel Fast, and how these dietary changes affect our selected hemodynamic, anthropometric, blood lipid, glucoregulatory, oxidative stress, inflammatory, renal, and hepatic biomarkers.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Must be 18 years of age or older.
- •Must be willing to partake in a vegan diet for 21 days.
- •Must be willing to consume either krill oil or coconut oil capsules (assigned randomly).
排除标准
- •regular consumption of antioxidant supplements
- •women who were pregnant or seeking to become pregnant
- •poor veins (veins that made it difficult to successfully obtain a blood draw - this was determined via a visual inspection)
结局指标
主要结局
Blood Lipids
时间窗: Change from baseline at 3 weeks
Total Cholesterol, LDL-C, HDL-C, VLDL-C, Triglyerides
Glucoregulatory markers
时间窗: Change from baseline at 3 weeks
Blood glucose, blood insulin, Serum resistin, serum adiponectin
Markers of Oxidative Stress and Antioxidant Status
时间窗: Change from baseline at 3 weeks
Plasma malondialdehyde, plasma hydrogen peroxide, plasma nitrate/nitrite, Trolox Equivalent Antioxidant Capacity (measured in serum)
Blood Pressure
时间窗: Change from baseline at 3 weeks
Systolic blood pressure, diastolic blood pressure
C-reactive protein
时间窗: Change from baseline at 3 weeks
次要结局
- Anthropometric Variables(Change from baseline at 3 weeks)
- Metabolic Panel(Change from baseline at 3 weeks)
- Complete Blood Count(Change from baseline at 3 weeks)