NCT05869513已完成不适用
The Effects of Krill Oil Supplementation on Adaptations in Muscle Strength, Function, Mass and Neuromuscular Function to a Pragmatic Home-based Resistance Exercise Intervention in Sedentary Older Adults: a Randomised Controlled Trial
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- Nueromuscular Junction (NMJ) transmission instability
研究概览
简要总结
The aim of this study is to determine whether krill oil supplementation enhances effects of a pragmatic resistance exercise programme on adaptations in muscle strength, mass, function and neuromuscular function in sedentary older adults. Hypothesis - krill oil supplementation will enhance the beneficial effects of resistance exercise on muscle strength, function, mass and neuromuscular function in sedentary older adults.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
盲法说明
All supplements will be matched for taste and look
入排标准
- 年龄范围
- 60 Years 至 90 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Over the age of 60 years
- •scoring a low level of physical activity based on international physical activity questionnaire (not meeting the recommend physical activity which is at least 600 MET-min per week).
排除标准
- •severe cardiovascular disease
- •seizure disorders
- •uncontrolled hypertension (>150/90mmHg at baseline measurement)
- •cancer or cancer that has been in remission <5 years
- •ambulatory impairments which would limit ability to perform assessments of muscle function
- •taking medication known to affect muscle (e.g. steroids)
- •have an implanted electronic device (e.g. pacemaker/defibrillator/insulin pump)
- •on anticoagulant therapy
- •allergies to seafood
- •regular consumption of more than 1 portion of oily fish per week
- •already taking fish or krill oil or other n3 PUFA supplements
- •femoral neck fracture or other severe of hip or knee operations
- •Parkinson's disease
- •kidney disease
- •hyperlipidaemia
- •osteoporosis.
结局指标
主要结局
Nueromuscular Junction (NMJ) transmission instability
时间窗: Change from baseline to 16 weeks
NMJ transmission instability will be measured by iEMG
次要结局
- Red Blood Cell Omega-3 levels(Change from baseline to 16 weeks)
- Muscle thickness(Change from baseline to 16 weeks)
- 30s chair stand test(Change from baseline to 16 weeks)
- Gait speed(Change from baseline to 16 weeks)
- Grip strength(Change from baseline to 16 weeks)
- Knee extensor maximal torque(Change from baseline to 8 16 weeks)
- Force steadiness during submaximal isometric knee extensor contractions(Change from baseline to 16 weeks)
研究者
Stuart Gray
Professor
University of Glasgow
研究点 (1)
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