The Efficacy of Scaling and Root Planing on Endothelin-1 Level

Not Applicable

Not yet recruiting

• Conditions: Periodontitis

• Registration Number: NCT06784869
• Lead Sponsor: University of Baghdad

Brief Summary

Periodontitis is a chronic inflammatory disease resulting from bacterial invasion. Endothelin (ET-1) is a potent vasoconstrictor critical in the pathophysiology of periodontal diseases.

Aim The present study aimed to measure the ET-1 concentrations in gingival crevicular fluid (GCF) at baseline, one and three months subsequently to non-surgical periodontal therapy.

Material and methods Designed as a clinical trial, 24 periodontitis individuals will be voluntarily consented to participate. Following non-surgical periodontal treatment, GCF samples will be collected to determine the amount of endothelin-1 at baseline, one, and three months. Clinical periodontal parameters will be recorded.

Detailed Description

Periodontitis is a chronic inflammatory disease resulting from bacterial invasion. Endothelin (ET-1) is a potent vasoconstrictor critical in the pathophysiology of periodontal diseases.

Aim The present study aimed to measure the ET-1 concentrations in gingival crevicular fluid (GCF) at baseline, one and three months subsequently to non-surgical periodontal therapy.

Material and methods Designed as a clinical trial, 24 periodontitis individuals will be voluntarily consented to participate. Following non-surgical periodontal treatment, GCF samples will be collected to determine the amount of endothelin-1 at baseline, one, and three months. Clinical periodontal parameters will be recorded.

Study Timeline

• Status Verified: 2025-01
• Study First Submitted: 2025-01-08
• Study First Submitted QC: 2025-01-15
• Last Update Submitted: 2025-01-15
• Study First Posted: 2025-01-20
• Last Update Posted: 2025-01-20
• Study Start: 2025-02-01
• Primary Completion: 2025-07-30
• Study Completion: 2025-09-30

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 24

Inclusion Criteria

• systemically healthy
• Generalized unstable periodontitis with a moderately deep pocket (4,5 or 6 mm)

Exclusion Criteria

• subjects who wore dental prosthesis
• teeth with grade II mobility,
• alcoholic and smoker, had treated caries
• underwent periodontal therapy within the last four months

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Primary Outcome Measures

Name	Time	Method
PPD	3 months recall visits	changes in PPD after non-surgical periodontal treatment.
CAL	3 months recall visits	changes in CAL after non-surgical periodontal treatment.

Secondary Outcome Measures

Name	Time	Method
ET-1	3 months recall visits	change in GCF level of Endothelin-1 in 1- and 3- month following the periodontal treatment