The effect of calcium ionophore on fertilization rate after intracytoplasmic sperm injection in infertile couples with advanced female reproductive age : a randomized controlled trial
Phase 4
- Conditions
- Infertile women that needs assisted reproductive technology by ICSI in advanced reproductive age group.Calcium ionophore, Artificial oocyte activation, ISCI, fertilization rate, Advanced reproductive age
- Registration Number
- TCTR20230302001
- Lead Sponsor
- Siriraj grant
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending (Not yet recruiting)
- Sex
- Female
- Target Recruitment
- 160
Inclusion Criteria
1.Infertile women that needs assisted reproductive technology by ICSI.
2.Infertile women from 35 years of age.
3.Diagnosed infertility by WHO criteria.
4.Cycle with more than or equal to 2 Metaphase II (MII) oocytes
Exclusion Criteria
1.Couple with a chromosomal abnormality either in male or female.
2.Abnormal semen in male partner.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Fertilization rate 6 months 2 pronuclei (2PN) zygotes/MII oocyte x 100
- Secondary Outcome Measures
Name Time Method Cleavage rate 6 months number of cleaved embryos on day 3/number of normally fertilized oocytes x 100,Good-quality cleavage rate 6 months number of good-quality cleavage embryos/number of normally fertilized oocytes x 100 ,Blastocyst formation rate 6 months number of blastocyst embryos/number of normally fertilized oocytes x 100 ,Good-quality blastocyst rate 6 months number of good-quality blastocyst embryos/number of normally fertilized oocytes x 100,Biochemical pregnancy rate 6 months number of positive hCG following embryo transfer/number of embryo transfer x 100 ,Clinical pregnancy rate 2 years number of positive fetal heart beat on ultrasonography/number of embryo transfer x 100 ,Live birth rate 2 years viable neonate at more than or equal to 28 weeks of gestation/number of embryo transfer x 100 ,Miscarriage rate 2 years number of pregnancy loss before gestational week 12/number of embryo transfer x 100