Calcium Ionophore Solution Can Increase Fertilization Rate in Patients During Intracytoplasmic Sperm Injection(ICSI) Who Have Poor Ovarian Reserve?

Not Applicable

• Conditions: Fertilization Failure
• Interventions: Other: calcium ionophore solution

• Registration Number: NCT02045914
• Lead Sponsor: Baskent University

Brief Summary

The aim of this study is to evaluate calcium ionophore solution on fertilization rate of patients during intracytoplasmic sperm injection who have poor ovarian reserve

Detailed Description

During ICSI cycle , female patients who have poor ovarian reserve have low oocyte numbers. So by calcium ionophore solution which we know that it can increase fertilization rate in males who have azospermia or globozoospermia. we planned to check if this solution can increase fertilization rate also in poor ovarian reserve patients?

Study Timeline

• Status Verified: 2014-01
• Study Start: 2014-01
• Study First Submitted: 2014-01-23
• Study First Submitted QC: 2014-01-23
• Last Update Submitted: 2014-01-23
• Study First Posted: 2014-01-27
• Last Update Posted: 2014-01-27
• Primary Completion: 2014-04
• Study Completion: 2014-08

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: Female
• Target Recruitment: 162

Inclusion Criteria

• infertile couples who have no male factor infertility
• infertile females who are poor ovarian reserve

Exclusion Criteria

• infertile couples who have male factor infertility
• infertile female who have endometriosis

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
calcium ionophore	calcium ionophore solution	the patients whose oocytes are incubated with calcium ionophore solution during ICSI cycle

Primary Outcome Measures

Name	Time	Method
calcium ionophore solution effect on fertilization rate	18 hours	Before Intracytoplasmic sperm injection adding calcium ionophore solution to the medium can increase fertilization rate of oocytes or not?

Secondary Outcome Measures

Name	Time	Method
Calcium ionophore solution increase on going pregnancy rate	up to 21 weeks	İf the calcium ionophore can increase fertilization rate , pregnancy rate up to 20 weeks, can increase or not?

Trial Locations

Locations (1)

baskent university obstetric and gynecology, reproductive endocrinology and IVF unit; 🇹🇷 Adana, Kisla, Turkey