Metacognition in Semantic Dementia: Comparison With Alzheimer's Disease

Completed

• Conditions: Healthy; Semantic Dementia; Alzheimer Disease
• Interventions: Other: Metacognition tests

• Registration Number: NCT04597827
• Lead Sponsor: University Hospital, Grenoble

Brief Summary

This study aims at exploring patients' ability to monitor their own memory performance depending on their primary deficit and the type of memory involved in the criterion task. The goal is to evaluate if semantic dementia (SD) and Alzheimer's disease (AD) differently affect patients' awareness of their memory abilities.

Detailed Description

Patients who will give their informed non-opposition will be included. Participants will undergo 6 metacognitive tasks in which they will be tested on newly learnt information (i.e., episodic memory) or prior knowledge (i.e., semantic memory) and asked to evaluate their performance either prior or after the test. Correlation between their evaluation and their actual performance will be measured. Performance and correlations will be compared across groups.

Study Timeline

• Study First Submitted: 2020-10-01
• Study Start: 2020-10-16
• Study First Submitted QC: 2020-10-16
• Study First Posted: 2020-10-22
• Primary Completion: 2022-04-27
• Study Completion: 2022-04-27
• Status Verified: 2023-08
• Last Update Submitted: 2023-08-04
• Last Update Posted: 2023-08-07

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

• native French-speakers
• normal or corrected-to-normal vision
• for patients ONLY : doctor-approved diagnosis of semantic dementia or Alzheimer's disease
• for healthy participants ONLY: score above 27 on the MMSE
• non-opposition in participation

Exclusion Criteria

• other neurological/ psychiatric disorder, or cognitive disorder that might affect general cognition
• drug or alcohol abuse

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Control	Metacognition tests	MMSE above 27, no neurological or psychiatric disorder
Semantic dementia	Metacognition tests	Diagnosis of semantic dementia (revised criteria Moreaud et al., 2008; based on Neary et al., 1998)
Alzheimer's disease	Metacognition tests	NIAAA 2011 criteria

Primary Outcome Measures

Name	Time	Method
Metacognitive bias on the semantic retrospective judgment task	End of study : around May 2022	Metacognitive bias will be assessed by subtracting the mean proportion of the metacognitive judgments to the actual memory performance. Bias will range from -1 (underestimation) to 1 (overestimation).
Metacognitive accuracy on the semantic retrospective judgment task	End of study : around May 2022	Metacognitive accuracy will be assessed by calculating a gamma correlation for each participant. Metacognition accuracy allows to evaluate people's ability to discriminate correct responses from incorrect responses. Gamma correlation range from -1 to 1.
Metacognitive bias on episodic global judgment task	End of study : around May 2022	Metacognitive bias will be assessed by subtracting the mean proportion of the metacognitive judgments to the actual memory performance. Bias will range from -1 (underestimation) to 1 (overestimation).
Metacognitive accuracy on the semantic predictive judgment task	End of study : around May 2022	Metacognitive accuracy will be assessed by calculating a gamma correlation for each participant. Metacognition accuracy allows to evaluate people's ability to discriminate correct responses from incorrect responses. Gamma correlation range from -1 to 1.
Metacognitive bias on semantic global judgment task	End of study : around May 2022	Metacognitive bias will be assessed by subtracting the mean proportion of the metacognitive judgments to the actual memory performance. Bias will range from -1 (underestimation) to 1 (overestimation).
Metacognitive bias on the episodic predictive judgment task	End of study : around May 2022	Metacognitive bias will be assessed by subtracting the mean proportion of the metacognitive judgments to the actual memory performance. Bias will range from -1 (underestimation) to 1 (overestimation).
Metacognitive bias on the semantic predictive judgment task	End of study : around May 2022	Metacognitive bias will be assessed by subtracting the mean proportion of the metacognitive judgments to the actual memory performance. Bias will range from -1 (underestimation) to 1 (overestimation).
Metacognitive bias on the episodic retrospective judgment task	End of study : around May 2022	Metacognitive bias will be assessed by subtracting the mean proportion of the metacognitive judgments to the actual memory performance. Bias will range from -1 (underestimation) to 1 (overestimation).
Metacognitive accuracy on the episodic predictive judgment task	End of study : around May 2022	Metacognitive accuracy will be assessed by calculating a gamma correlation for each participant. Metacognition accuracy allows to evaluate people's ability to discriminate correct responses from incorrect responses. Gamma correlation range from -1 to 1.
Metacognitive accuracy on the episodic retrospective judgment task	End of study : around May 2022	Metacognitive accuracy will be assessed by calculating a gamma correlation for each participant. Metacognition accuracy allows to evaluate people's ability to discriminate correct responses from incorrect responses. Gamma correlation range from -1 to 1.

Trial Locations

Locations (7)

CHU Rennes; 🇫🇷 Rennes, France

Hôpitaux Civils Colmar; 🇫🇷 Colmar, France

Chu Grenoble Alpes; 🇫🇷 Grenoble, France

CHU Bordeaux; 🇫🇷 Bordeaux, France

Hôpital Neurologique de Lyon; 🇫🇷 Bron, France

CHU Angers; 🇫🇷 Angers, France

CHU Vaudois; 🇨🇭 Lausanne, Switzerland