Effect of two different anaesthetic drugs (propofol versus desflurane) on higher mental functions undergoing neurosurgery for brsin haemorrhage

Completed

• Conditions: aSAH Patients with ASA 1,2or3 with Hunt & Hess grade 1,2 or 3 with WFNS grade 1,2 or3

• Registration Number: CTRI/2015/01/005425
• Lead Sponsor: PGIMER CHANDIGARH

Brief Summary

Anaesthesiologist commonly use TIVA or inhalational agent in aneurysmal surgery. There is no randanmised trial comparing their effects in SAH patients undergoing craniotomy and clipping surgery.Both propofol and desflurane have the advantage of fast awakening and are popularin neurosurgical practice. Hence, this study is designed to prospectively evaluate the effects of propofol and desflurane on POCD in patients of aSAH undergoing craniotomy and clipping of aneurysmal neck.

Detailed Description

Not available

Study Timeline

• Study Start: 2013-05-07
• Last Update Posted: 2015-01-14

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

• Inclusion Criteria (1)Patients scheduled for aSAH surgery with clinical and radiological evidence of cerebral aneurysm.
• (2)Age between 18 to 65 yrs.
• (3)H and H grade 1 ,2 & 3 and WFNS grade 1, 2 & 3.
• (4)ASA 1, ASA 2 and ASA 3 will be included.

Exclusion Criteria

• Exclusion Criteria (1)Patients with systemic disease other than hypertension and diabetes mellitus.
• (2) Patients with infectious diseases and respiratory complications.
• (3) Duration of anesthesia more than six hours.
• (4) Second operation.
• (5) Low level of education.
• (6) Patients with known psychiatric disease.
• (7) Cardiovascular disease and respiratory impairment.
• (8) History of drug abuse.
• (9) Known allergy to any of the anesthetic agent to be used in study.
• (10)Patients who are unconscious, intubated or tracheostomised even after two weeks following exposure to anesthesia will also be excluded from the study.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
comparision of POCD between study group desflurane and propofol postoperatively	MOCA score 0 to 30

Secondary Outcome Measures

Name	Time	Method
comparision of haemodynamics and brain bulge between study groups desflurane and propofol intraoperatively	brain bulge score 0 to4

Trial Locations

Locations (1)

PGIMER , CHANDIGARH; 🇮🇳 Chandigarh, CHANDIGARH, India

PGIMER , CHANDIGARH

🇮🇳Chandigarh, CHANDIGARH, India

NANISH SHARMA

Principal investigator

8727049007

nanish.sharma26@gmail.com