Efficacy of transcranial direct current stimulation (tDCS) in modulating neurocognitive markers of obsessive-compulsive disorder

Not Applicable

• Conditions: F42.0; F42.1; F42.2; Predominantly obsessional thoughts or ruminations; Predominantly compulsive acts [obsessional rituals]; Mixed obsessional thoughts and acts

• Registration Number: DRKS00016807
• Lead Sponsor: Humboldt-Universität zu Berlin

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2019-03-05
• Study Completion: 2020-08-03
• Results First Posted: 2022-07-14
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

Inclusion criterion for patients: Primary diagnosis of obsessive-compulsive disorder (ICD-10, F42.-) as assessed by the Structured Clinical Interview for DSM-V Axis I Disorders
- German as native language
- Ability to provide written informed consent

Exclusion Criteria

- Current or lifetime diagnosis of a substance-related disorder, schizophrenia spectrum disorder, delusional disorder, bipolar disorder, neurological disorder of the CNS
- Verbal IQ < 85
- Uncorrectable visual, auditory, or motor impairments
- Benzodiazepines within the last week, neuroleptics during the last three months
- Contraindications for transcranial direct current stimulation: any metal or electronic implants in the head or upper body (e.g., cochlear implant, brain stimulator, aneurysm clip or stent, cardiac pacemaker), skin disorder or skin condition at or near stimulation locations (e.g., psoriasis or eczema), pregnancy

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Performance monitoring: <br>- Behavioral performance (reaction time and accuracy) and event-related potentials (ERN, Pe, CRN) during the flanker task at session 1 and session 2<br><br>Affective evaluation of self-generated actions: <br>- Behavioral performance (reaction time and accuracy) and event-related potentials (ERN, Pe, CRN) during the evaluative go/no-go task (go/no-go task combined with an affective word categorization task) at session 1 and session 2<br>- Skin conductance response and heart rate during the flanker task and the evaluative go/no-go task at session 1 and session 2