Comparison of letrozole and anastrozole in improving semen profile of subferile me

Phase 2

• Conditions: Health Condition 1: N461- Oligospermia

• Registration Number: CTRI/2024/04/066322
• Lead Sponsor: Jawaharlal Institute of Postgraduate Medical Education and Research

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 29 April 2024

Recruitment & Eligibility

• Status: ot Yet Recruiting
• Sex: Not specified
• Target Recruitment: 0

Inclusion Criteria

1. Subfertile men with moderate to severe oligoasthenozoospermia attending male infertility clinic, WCH, JIPMER during the study period.

Exclusion Criteria

1. Ejaculatory duct obstruction or surgery for male factor infertility

2.History of mumps orchitis, chronic tobacco and alcohol abuse.

3.Ongoing medical treatment including gonadotropins, anabolic steroids, and cancer chemotherapy

4. Leucocytospermia (more than 1 million/ml).

5. Severe varicocele and previously diagnosed Klinefelter syndrome.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To compare the effect of letrozole and anastrozole on semen parameters amongst men with Oligoasthenoteratozoospermia.Timepoint: At end of study (2years approx)

Secondary Outcome Measures

Name	Time	Method
1. To monitor the side effects of letrozole and anastrozole <br/ ><br>2. To measure the alterations in serum oestradiol and testosterone produced by letrozole and anastrozole.Timepoint: At end of study (2years approx)