Synergistic Effect of Locally Injected Vitamin D3 and Injectable Platelet Rich Fibrin (i-PRF) on the Rate of Maxillary Canine Retraction, and Expression of Various Biomarkers in Gingival Crevicular Fluid (GCF) During Comprehensive Orthodontic Treatment: A Randomized Split Mouth Comparative Study

Long duration of orthodontic treatment is a major problem in adult patients. Thus Orthodontic professionals are constantly looking for ways to accelerate orthodontic tooth movement thereby reducing the treatment duration. Adults show lagging cell mobilization rates, irregular arrangement of collagen fibers, and are more prone for periodontal diseases in comparison to the younger patients. Therefore, shortening the duration of treatment by hastening the tooth movement is challenging for orthodontists. There are number of techniques available to augment the rate of orthodontic tooth movement and they can be invasive or non-invasive. Presently, Vitamin D and i-PRF are used for the process of bone remodeling. There are limited studies in literature mentioning benefits of i-PRF and Vitamin D on the acceleration of orthodontic tooth movement. The benefits of i-PRF and Vitamin D remains for a period of 4 weeks and 2 weeks 8 respectively. The combined use of i-PRF and Vitamin D can be beneficial for the orthodontic tooth movement. There is no study in the literature mentioning the synergistic effects of i-PRF and Vitamin D on orthodontic tooth movement. Hence the current study is planned to evaluate the synergistic effects of i-PRF and Vitamin D on the rate of orthodontic tooth movement and to correlate the same with the expression of various biomarkers in GCF during comprehensive orthodontic treatment.