15-month longitudinal study of dietary and sunlight influences on vitamin D status in a well-characterised population of postmenopausal women at 57º
Completed
- Conditions
- ow bone mass/risk of osteoporosisMusculoskeletal DiseasesOsteoporosis
- Registration Number
- ISRCTN96210443
- Lead Sponsor
- Food Standards Agency (UK)
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Female
- Target Recruitment
- 360
Inclusion Criteria
Women from a previous sceening study (Aberdeen Prospective Osteoporosis Screening Study - APOSS) aged less than 65 years.
Exclusion Criteria
Participants will be excluded if they:
1. Have chronic gastro-intestinal disease associated with malabsorption
2. Are taking oral corticosteroids
3. Are receiving bisphosphonate therapy (as there is a possibility of interaction with vitamin D metabolism)
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Monitor longitudinally the seasonal variation in vitamin D status at a northerly latitude, assessing the individual contributions of sunlight and diet.<br><br>All primary and secondary outcomes were measured at each visits, i.e., at Baseline (BL), 3-month, 6-month, 9-month and 12-month visits.
- Secondary Outcome Measures
Name Time Method 1. Monitor seasonal variation in physical activity (confounder of vitamin D status)<br>2. Monitor seasonal variation in:<br>2.1. Markers of bone turnover (functional marker)<br>2.2. Falls, muscle strength (functional markers not related to bone health)<br>3. Determine the relationship between vitamin D status, functional markers (Bone Mineral Density [BMD], bone resorption, muscle strength) with and without adjustment for physical activity level<br><br>All primary and secondary outcomes were measured at each visits, i.e., at Baseline (BL), 3-month, 6-month, 9-month and 12-month visits; BMD was measured at 6-month and 9-month visits only.