MedPath

Effects of Electronic Cigarette Settings and Liquid Concentrations in Cigarette Smokers and Electronic Cigarette Users

Not Applicable
Completed
Conditions
Electronic Cigarettes
Interventions
Other: ECIG Lab Session 15 watts, 10 mg nicotine
Other: ECIG Lab Session 15 watts, 15 mg nicotine
Other: ECIG Lab Session 15 watts, 30 mg nicotine
Other: ECIG Lab Session 30 watts, 10 mg nicotine
Other: ECIG Lab Session 30 watts, 15 mg nicotine
Other: ECIG Lab Session 30 watts, 30 mg nicotine
Registration Number
NCT03710590
Lead Sponsor
Virginia Commonwealth University
Brief Summary

The purpose of this research study is to find out how different types of electronic cigarettes (ECIG) settings, combined with e-liquids of differing nicotine concentrations, affect blood nicotine levels, use behavior (how users puff), and how users feel.

Detailed Description

Not available

Recruitment & Eligibility

Status
COMPLETED
Sex
All
Target Recruitment
45
Inclusion Criteria

Not provided

Read More
Exclusion Criteria
  • Women if they are breast-feeding or test positive for pregnancy (by urinalysis) at screening.
  • Individuals who weigh less than 110 pounds

Some study details about the eligibility criteria are purposely omitted at this time to preserve scientific integrity. Full details will be posted at the conclusion of the study.

Read More

Study & Design

Study Type
INTERVENTIONAL
Study Design
CROSSOVER
Arm && Interventions
GroupInterventionDescription
Cigarette smokersECIG Lab Session 15 watts, 15 mg nicotine-
Cigarette smokersECIG Lab Session 30 watts, 10 mg nicotine-
Cigarette smokersECIG Lab Session 30 watts, 15 mg nicotine-
Cigarette smokersECIG Lab Session 30 watts, 30 mg nicotine-
Cigarette smokersECIG Lab Session 15 watts, 30 mg nicotine-
Cigarette smokersECIG Lab Session 15 watts, 10 mg nicotine-
Electronic cigarette usersECIG Lab Session 15 watts, 10 mg nicotine-
Electronic cigarette usersECIG Lab Session 15 watts, 15 mg nicotine-
Electronic cigarette usersECIG Lab Session 30 watts, 15 mg nicotine-
Electronic cigarette usersECIG Lab Session 15 watts, 30 mg nicotine-
Electronic cigarette usersECIG Lab Session 30 watts, 10 mg nicotine-
Electronic cigarette usersECIG Lab Session 30 watts, 30 mg nicotine-
Primary Outcome Measures
NameTimeMethod
Change in Plasma NicotineBaseline to 5 min after the start of a 10-puff product use

Change in plasma nicotine level.

Puff VolumeEach time the e-cigarette is used during the 10-puff use bout - 5 minutes

The average volume of each puff, in ml, during 10 puff bout.

Puff DurationEach time the e-cigarette is used during the 10-puff use bout - 5 minutes

The average duration of each puff, in seconds.

Secondary Outcome Measures
NameTimeMethod
Heart RateHeart rate will be measured from baseline continuously throughout the 10-puff bout - 5 minutes

Average heart rate, measured in beats per minute.

Trial Locations

Locations (1)

Clinical Behavioral Pharmacolgy Laboratory

🇺🇸

Richmond, Virginia, United States

© Copyright 2025. All Rights Reserved by MedPath