Functional magnetic resonance imaging of human hypothalamic responses to oral glucose ingestion in obese and lean subjects

Suspended

• Conditions: corpulence; Obesity; 10003018

• Registration Number: NL-OMON41891
• Lead Sponsor: eids Universitair Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 23 April 2024

Recruitment & Eligibility

• Status: Suspended
• Sex: Not specified
• Target Recruitment: 28

Inclusion Criteria

BMI >30 for obese subjects and BMI 19-25 for lean subjects
Age 21-30 years
Male

Exclusion Criteria

History of diabetes or medication influencing glucose metabolism
Relevant genetic or psychiatric disease
Chronic disease
Renal or hepatic disease
Recent weight loss > 5 kg within the last 3 months
Smoking
Alcohol consumption > 21 units per week
Use of recreational drugs during the last year
Recent blood donation (< 2 months)
Recent participation in other biomedical research projects (within the last 3 months), participation in 2 or more biomedical research projects in on year
MRI contra-indications (i.e. claustrophobia, ferromagnetic implants)

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>BOLD signal intensity changes of the hypothalamus after ingestion of 2<br /><br>different stimuli (300 ml each): water at room temperature and glucose solution<br /><br>at room temperature. The last stimulus will contain 75g of glucose. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>BOLD responses in amygdala and nucleus accumbens<br /><br>Z-scores of functional connectivity (rs-fMRI)<br /><br>Psychophysical ratings of hunger and pleasantness of taste scored by VAS</p><br>