Functional magnetic resonance imaging of human hypothalamic responses to taste, temperature and glucose sensing
- Conditions
- gezonde vrijwilligershealthy volunteers
- Registration Number
- NL-OMON38570
- Lead Sponsor
- nilever
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 15
-Signed informed consent
-Age between 18 and 25 years
-BMI between 20 and 23 kg/m2
-Length between 170 and 190 centimeters
Diabetes
Any genetic or psychiatric disease (e.g. fragile X syndrome, major depression) affecting brain
Any significant chronic disease
Renal or hepatic disease
Recent weight changes or attempts to loose weight (> 3 kg weight gain or loss, within the last 3 months)
Smoking (current or last 6 months)
Alcohol consumption of more than 21 units per week or use of recreational drugs at present or in the last year
Recent blood donation (within the last 2 months)
Recent participation in other biomedical research projects (within the last 3 months), participation in 3 or more biomedical research projects in one year
Contra-indication to MRI scanning
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>BOLD signal intenstity changes of the hypothalamus after ingestion of 5<br /><br>different stimuli (300 ml each): water at room temperature, water with<br /><br>ethyl-butyrate (pineapple food-flavouring) at room temperature, glucose<br /><br>solution at room temperature, glucose solution with ethyl-butyrate at room<br /><br>temperature and glucose solution with ethyl-butyrate at 0 degrees Celsius<br /><br>(glucose solutions contain 50 gram of glucose, ethyl-butyrate is a common food<br /><br>flavouring with a pineapple taste).</p><br>
- Secondary Outcome Measures
Name Time Method <p>BOLD responses in the amygdala ad nucleus accumbens<br /><br>Psychophysical ratings of temperature and pleasantness of taste</p><br>