Functional magnetic resonance imaging of human hypothalamic responses to glucose, fructose, sucrose, and sucralose.

Completed

• Conditions: gezonde vrijwilligers; healthy volunteers

• Registration Number: NL-OMON42119
• Lead Sponsor: nilever

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 23 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 16

Inclusion Criteria

-Signed informed consent
-Age between 18 and 25 years
-BMI between 20 and 24kg/m2
-Length between 170 and 190 centimeters

Exclusion Criteria

-Diabetes
-Any genetic or psychiatric disease (e.g. fragile X syndrome, major depression) affecting brain
-Any significant chronic disease
-Renal or hepatic disease
-Recent weight changes or attempts to lose weight (> 3 kg weight gain or loss, within the last 3 months)
-Smoking (current or last 6 months)
-Alcohol consumption of more than 21 units per week or use of recreational drugs at present or in the last year
-Recent blood donation (within the last 2 months)
-Recent participation in other biomedical research projects (within the last 3 months), participation in 3 or more biomedical research projects in one year
-Contra-indication to MRI scanning

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>BOLD signal intensity changes of the hypothalamus after ingestion of 5<br /><br>different stimuli of 300ml each: tap water, 50gr glucose solution, 50 gr<br /><br>fructose solution, 50gr sucrose solution and 0,1gr sucralose solution.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Psychophysical ratings of hunger, taste and sweetness</p><br>