The Effect of Adding Epinephrine To Combination of 0.75% Ropivacaineand Dexmedetomidine in Intrathecal Anaesthesia- A Prospective, DoubleBlinded Randomized Control Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- Duration of analgesia
研究概览
简要总结
The study is designed to evaluate intrathecal anaesthesia and postoperative analgesia by adding epinephrine to combination of ropivacaine and dexmedetomidine.
In earlier studies dexmedetomidine with ropivacaine provids early sensory blockade, prolonged duration of sensory and motor blockade in patients undergoing intrathecal anesthesia for lower limb surgeries with no sedation. On the other hand epinephrine, a vasoconstrictor, reduces absorption of local anesthetics into the bloodstream when used as an adjuvant. Therefore, it reduces the systemic toxicity of local anesthetics and extends the duration of anesthesia.
We hypothesized that intrathecal isobaric 0.75% ropivacaine with dexmedetomidine and 1:1000 adrenaline would be comparable to isobaric 0.75% ropivacaine with dexmedetomidine and normal saline, for the efficacy of anesthesia and analgesia, and in addition would provide a better postoperative recovery profile and readiness for discharge. The purpose of the present study is to observe the effect of mentioned study drugs in intrathecal anaesthesia for duration of sensory and motor block with duration analgesia.
研究设计
- 研究类型
- Interventional
- 分配方式
- Computer generated randomization
- 盲法
- Participant, Investigator and Outcome Assessor Blinded
入排标准
- 年龄范围
- 15.00 Year(s) 至 60.00 Year(s)（—）
- 性别
- All
入选标准
- •ASA 1 & 2 Lower limb surgery of probable duration of 2hrs.
排除标准
- •Patients refusal Contradiction to regional anaesthesia Coagulopathy History of significant coexisting diseases like ischemic heart disease, hypertension, impaired renal functions, rheumatoid arthritis, and severe liver disease Pregnant patients Chronic alcoholics and malnourished patients Atrioventricular block, incomplete or partial heart blocks or intake of beta-blockers.
结局指标
主要结局
Duration of analgesia
时间窗: After 2 hours every 15 minutes
次要结局
- Duration of sensory block and motor block(After 2 hours every 15 minutes)