EFFECT OF ADDING EPINEPHRINE TO COMBINATION OF ISOBARIC ROPIVACAINE AND DEXMEDETOMIDINE IN SPINAL ANAESTHESIA

Completed

Conditions: Medical and Surgical, (2) ICD-10 Condition: V99||Unspecified transport accident,

Registration Number: CTRI/2021/01/030445

Lead Sponsor: NOT APPLICABLE

Brief Summary: The study is designed to evaluate intrathecal anaesthesia and postoperative analgesia by adding epinephrine to combination of ropivacaine and dexmedetomidine.

In earlier studies dexmedetomidine with ropivacaine provids early sensory blockade, prolonged duration of sensory and motor blockade in patients undergoing intrathecal anesthesia for lower limb surgeries with no sedation. On the other hand epinephrine, a vasoconstrictor, reduces absorption of local anesthetics into the bloodstream when used as an adjuvant. Therefore, it reduces the systemic toxicity of local anesthetics and extends the duration of anesthesia.

We hypothesized that intrathecal isobaric 0.75% ropivacaine with dexmedetomidine and 1:1000 adrenaline would be comparable to isobaric 0.75% ropivacaine with dexmedetomidine and normal saline, for the efficacy of anesthesia and analgesia, and in addition would provide a better postoperative recovery profile and readiness for discharge. The purpose of the present study is to observe the effect of mentioned study drugs in intrathecal anaesthesia for duration of sensory and motor block with duration analgesia.

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: All

Target Recruitment: 50

Inclusion Criteria

ASA 1 & 2 Lower limb surgery of probable duration of 2hrs.

Exclusion Criteria

Patients refusal Contradiction to regional anaesthesia Coagulopathy History of significant coexisting diseases like ischemic heart disease, hypertension, impaired renal functions, rheumatoid arthritis, and severe liver disease Pregnant patients Chronic alcoholics and malnourished patients Atrioventricular block, incomplete or partial heart blocks or intake of beta-blockers.

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Duration of analgesia	After 2 hours every 15 minutes

Secondary Outcome Measures

Name	Time	Method
Duration of sensory block and motor block	After 2 hours every 15 minutes

Trial Locations

Locations (1): TRAUMA CENTER INSTITUTE OF MEDICAL SCIENCES BHU
🇮🇳
Varanasi, UTTAR PRADESH, India
TRAUMA CENTER INSTITUTE OF MEDICAL SCIENCES BHU
🇮🇳Varanasi, UTTAR PRADESH, India
DR SANDEEP LOHA
Principal investigator
8660919866
drsandeepscb@gmail.com