Sugar, non-caloric sweeteners and reward

Completed

Conditions: obesitas
obesity
overweight

Registration Number: NL-OMON35205

Lead Sponsor: Wageningen Universiteit

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 40

Inclusion Criteria

Zie pag. 11 van protocol;• Age: 18-35 years
• BMI: 18.5 - 25.0 kg/m2
• Healthy (as judged by the participant)

Exclusion Criteria

Zie pag. 11 van protocol
• Restraint eating (men: score > 2.25; women: score > 2.80) [8]
• Lack of appetite
• Having difficulties with swallowing/eating
• Usage of an energy restricted diet during the last two months
• Weight loss or weight gain of 5 kg or more during the last two months
• Stomach or bowel diseases
• Diabetes, thyroid disease, other endocrine disorders
• Having a history of neurological disorders
• Having taste or smell disorders
• Usage of daily medication other than birth control pills
• For females: being pregnant or lactating
• Smoking more than one cigarette a day
• Being allergic/intolerant for products under study
• Exclusive consumption of *light* versions of yoghurt and/or soft drinks
• Working at the division of human nutrition (WUR)
• Current participation in other research from the division of human nutrition (WUR)
• For males: having a contra-indication to MRI scanning (see page 11 of the protocol)

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The primary outcome measures of this study are 1) the shift in product<br /><br>preference, i.e., the difference in choice for the sugar sweetened and<br /><br>non-caloric sweetened yoghurt drinks and the sugar sweetened and non-caloric<br /><br>sweetened soft drinks (males and females) after repeated exposure and 2) the<br /><br>change in brain reward responses to the sugar sweetened and non-caloric<br /><br>sweetened drinks after repeated exposure (males). </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>The secondary objective of this study is to determine the effect of replacing<br /><br>added sugar by non-caloric sweeteners in a nutrient-rich matrix (dairy drink<br /><br>yoghurt) and in a nutrient-empty matrix (soft drink) after repeated consumption<br /><br>on:<br /><br>• Explicit and implicit liking and wanting of these products.<br /><br>• Implicit associations of these products with feelings of satiety.<br /><br>• Expected satiety of these products.<br /><br>• Ad libitum intake of these products</p><br>