Study to compare the effect of blood flow restriction training and russian current along with resistance exercises in reducing pain and improving function in early knee osteoarthritis.

Not yet recruiting

Conditions: Bilateral primary osteoarthritis of knee,

Registration Number: CTRI/2025/05/087634

Lead Sponsor: Uttar Pradesh University Of Medical Sciences

Brief Summary: This randomized controlled trial investigates the comparative efficacy of Blood Flow Restriction Training (BFRT) and Russian current therapy, each combined with resistance training and a home exercise program, in patients with early knee osteoarthritis (OA). Participants aged 45–70 years with Grade 1 or 2 knee OA (per Kellgren-Lawrence classification) will be recruited from the Orthopaedics OPD at UPUMS, Safai. A total of 114 participants will be randomly assigned to two groups (n=57 each) using computer-generated randomization.

**Intervention Protocols:** Group A will receive BFRT with resistance training, performed three times per week for 4 weeks, using pressure based on Australian Sports Commission guidelines. Group B will receive Russian current (50 Hz, 15 mins) with similar resistance training. Both groups will also follow a standardized home exercise program including quadriceps drills, hamstring curls, and stretching, with hot fomentation post-exercise.

**Outcome Measures:** Baseline and post-intervention assessments at 4 weeks and 2-week follow-up will include pain (NRS, algometer), range of motion (digital goniometer), muscle strength (MMT), and functional disability (WOMAC). Validity and reliability of all outcome tools are well-established.

**Statistical Analysis:** Data will be analyzed using SPSS software. Independent t-tests and ANOVA will determine the significance of differences between groups.

**Hypothesis:** The alternative hypothesis suggests a significant difference in outcomes between BFRT and Russian current interventions, while the null hypothesis posits no significant difference.

**Novelty:** This study is novel in its direct comparison of BFRT and Russian current combined with resistance training in early knee OA. It emphasizes early-stage intervention, integrates both objective and subjective outcomes, and has the potential to inform clinical guidelines for preventive OA management.

Detailed Description: Not available

Recruitment & Eligibility

Status: Not Yet Recruiting

Sex: All

Target Recruitment: 114

Inclusion Criteria

Age group: 45 to 70 yrs 2.
Patient with both unilateral and bilateral knee pain.
Patients in early phase: Grade 1 and 2, According to Kellgren Lawrence classification 4.No contraindication to physical activity or electrical stimulation.
Both male and Female.

Exclusion Criteria

Metabolic bone disorders.
Use of corticosteroids or local injections for knee OA in past 6 months.
Skin diseases.
4.Patient with cardiovascular diseases.
6.Patients with bony ankylosis.
7.Neuropathic joint diseases.
History of trauma.

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Pain intensity,Range of motion, muscle strength,functional disability.	At Baseline,at 4 weeks and 8 weeks.

Secondary Outcome Measures

Name	Time	Method

Trial Locations

Locations (1): Uttar Pradesh University of Medical Sciences,Saifai,Etawah, UP.
🇮🇳
Etawah, UTTAR PRADESH, India
Uttar Pradesh University of Medical Sciences,Saifai,Etawah, UP.
🇮🇳Etawah, UTTAR PRADESH, India
Dr Bhavna Verma PT
Principal investigator
8755512277
vbhavna632@gmail.com