A Comparison of Naropin and Ketorolac for Postoperative Analgesia After Total Knee Arthroplasty

Phase 4

Completed

• Conditions: Postoperative Pain
• Interventions: Drug: Saline; Drug: Ketorolac

• Registration Number: NCT00868348
• Lead Sponsor: University of Aarhus

Brief Summary

The purpose of this study is to determine wether ketorolac is effective in the treatment of postoperative pain after total knee arthroplasty

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2009-03-24
• Study First Submitted QC: 2009-03-24
• Study First Posted: 2009-03-25
• Study Start: 2009-05
• Primary Completion: 2011-06
• Study Completion: 2011-09
• Status Verified: 2013-07
• Results First Submitted: 2013-07-10
• Results First Submitted QC: 2014-01-22
• Last Update Submitted: 2014-01-22
• Results First Posted: 2014-03-10
• Last Update Posted: 2014-03-10

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

• Total knee arthroplasty
• Age > 18
• Tolerance for study drugs
• Written informed consent

Exclusion Criteria

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Saline	Saline	-
Ketorolac	Ketorolac	-

Primary Outcome Measures

Name	Time	Method
Morphine Consumption	48 hours after surgery	Consumption of intravenous (i.v.) patient-controlled analgesia (PCA) morphine during the first forty-eight hours after surgery

Secondary Outcome Measures

Name	Time	Method
Time to First i.v. Patient Controlled Analgesia (PCA) Morphine Request	within 48 hours after surgery
Pain Intensity Scores During Walking	6-24 hours postoperatively	Pain intensity Visual Analogue Scale (VAS) (VAS; 0, no pain, and 100 mm, worst pain possible)
Home Readiness	time to fulfilment of discharge criteria	Ability to meet discharge criteria (home readiness)
Length of Hospital Stay	From the day of surgery until discharge
Pain Intensity During Daily Activity	16 weeks after surgery	Pain intensity Visual Analogue Scale (VAS) (VAS; 0, no pain, and 100 mm, worst pain possible)

Trial Locations

Locations (1)

Aarhus University; 🇩🇰 Aarhus, Denmark