Egg Cholesterol Consumption, Blood Cholesterol and Skeletal Muscle Hypertrophy

Phase 2

• Conditions: Cardiovascular Disease; Sarcopenia
• Interventions: Behavioral: Resistance Training; Behavioral: Sedentary

• Registration Number: NCT00260442
• Lead Sponsor: Texas A&M University

Brief Summary

The purpose of this study is to examine the effect of dietary cholesterol administered as whole egg or egg white (control)on muscle mass gain with resistance training in a young old population of men and women (age 50-69). It is hypothesized that dietary cholesterol will be significantly associated to muscle mass gain.

Detailed Description

The primary objective of this proposal is to have 36 men and women (age 50-69) perform 12 weeks of resistance exercise training for the purpose of inducing skeletal muscle hypertrophy. These individuals will consume either 0, 1, or 3 whole eggs per day in a double-blind design to test the hypothesis that dietary cholesterol is essential for skeletal muscle hypertrophy. If so proven, this will confirm a very strong association between dietary cholesterol and hypertrophy observed in a previous study of 51 men and women (age 60-69). The current proposal is using a randomized double-blind, placebo controlled design to provide the most conclusive evidence that dietary cholesterol plays an essential role in skeletal muscle hypertrophy.

The secondary objective of this proposal is to test the hypothesis that increased dietary cholesterol consumption in the context of an exercise program does not alter blood cholesterol concentrations or other cardiovascular risk factors.

Study Timeline

• Study Start: 2005-11
• Study First Submitted: 2005-11-29
• Study First Submitted QC: 2005-11-29
• Study First Posted: 2005-12-01
• Primary Completion: 2008-05
• Status Verified: 2015-11
• Last Update Submitted: 2015-11-04
• Last Update Posted: 2015-11-05
• Study Completion: 2017-05

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 36

Inclusion Criteria

• men and women aged 50-69
• able to perform exercise testing and training

Exclusion Criteria

• blood pressure > 160/100
• cardiac arrhythmias
• cancer
• hernia
• aortic aneurysm
• kidney disease
• lung disease
• total cholesterol > 240 mg/dl or < 160 mg/dl
• current use of cholesterol lowering medications
• actively participating in >1 hour per week of resistance training

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Average intake	Resistance Training	400 mg/day dietary cholesterol, resistance training, sedentary
Average intake	Sedentary	400 mg/day dietary cholesterol, resistance training, sedentary
Placebo	Sedentary	\< 200 mg/day dietary cholesterol, resistance training, sedentary
Placebo	Resistance Training	\< 200 mg/day dietary cholesterol, resistance training, sedentary
High intake	Resistance Training	800 mg/day dietary cholesterol, resistance training, sedentary
High intake	Sedentary	800 mg/day dietary cholesterol, resistance training, sedentary

Primary Outcome Measures

Name	Time	Method
Primary: Strength and muscle gain (DEXA)	after 12 weeks of resistance training

Secondary Outcome Measures

Name	Time	Method
Secondary: Blood lipids, inflammatory markers, blood pressure	after 12 weeks of resistance training

Trial Locations

Locations (1)

Texas A&M University; 🇺🇸 College Station, Texas, United States