Effect of vitamin D on inflammation and muscle damage in athletes
- Conditions
- Condition 1: inflammation. Condition 2: muscle damage.-
- Registration Number
- IRCT2017042613678N27
- Lead Sponsor
- Vice Chancellor for research of Urmia university of medical sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- Male
- Target Recruitment
- 22
inclusion criteria: soccer players who want to collaboration; players who regularly and consistently participate in soccer practices and matches(at least 4 month passed from starting this sport); age group between 18 to 30 years old; healthy players without any injury, cardio-metabolic disease, orthopedic and inflammatory disease; players without any acute liver disease, biliary, kidney and digestive disease; players with no history of kidney stone and hyperparathyroidism and osteomalasia or osteoporosis and sarcoidosis; lack of vitamin D supplementation at least for 8 weeks before the study beginning; lack of using drugs which can affect vitamin D level and its metabolism and function such as steroid and anti-epileptic drugs; lack of using certain drugs such as acetaminophen and anti-inflammatory drugs and b blockers and statins; lack of using exogenous hormones; lack of using amphotericin B,ampicilin, anticoagulant drugs, aspirin, clofibrate, cocaine, lithium, furosemide, morphine and some of anesthetic drugs; lack of using epinephrine and sodium bicarbonate; lack of using orlistate and cholestyramine and other cholesterol reducing drugs; people by BMI group 18.5 to 30; lack of smoking and alcohol consumption; people with 25(oh)D serum concentration less than 40 ng/mL.
exclusion criteria: lack of collaboration for continuing the study; using certain drugs during the study; using foods rich in vitamin D specially canned fish, cod fish oil, Salmon and vit D fortified foods; using less than 80 % of supplements; traveling to place with sunny weather during the study; injury or disease occurrence during the study.
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Interleukin 6. Timepoint: at the end of the trial: before the simulated test, immediately after the test, 2 and 24 hours after the test. Method of measurement: lab test.;CRP. Timepoint: at the end of the trial: before the simulated test, immediately after the test, 2 and 24 hours after the test. Method of measurement: lab test.;Lactate dehydrogenase. Timepoint: at the end of the trial: before the simulated test, immediately after the test, 2 and 24 hours after the test. Method of measurement: lab test.;Creatine phosphate kinase. Timepoint: at the end of the trial: before the simulated test, immediately after the test, 2 and 24 hours after the test. Method of measurement: lab test.;Serum 25-oh vitamin D3 level. Timepoint: before and after the trial: immidiately before the soccer simulated test. Method of measurement: lab test.;Body composition. Timepoint: Before intervention and 8 weeks after intervention. Method of measurement: Body composition analyzer (BIA).
- Secondary Outcome Measures
Name Time Method Rating of Perceived Exertion. Timepoint: immidiately after each partof the simulated test. Method of measurement: questionnaire.