Immune effects of acidic and neutral oligosaccharides in the nutrition of preterm infants: CARROT study

Completed

• Conditions: Prebiotics, gastrointestinal tract, preterm infants, immune effects; Nutritional, Metabolic, Endocrine; Nutrition of preterm infants

• Registration Number: ISRCTN16211826
• Lead Sponsor: VU University Medical Centre (VUMC) (Netherlands)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2007-02-08
• Last Update Posted: 13 January 2015

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 108

Inclusion Criteria

Infants born with a gestational age of less than 32 weeks and/or a birthweight of less than 1500g

Exclusion Criteria

1. Severe congenital disorders, like cardiac disorders, syndromal disorders, immunodeficiency disorders
2. Congenital disorders of the gastrointestinal tract

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
1. The effect of acidic and neutral oligosaccharides supplemented enteral feeding on infectious morbidity<br>2. The incidence of serious infections, using the previously described criteria for serious infections in preterm infants at high risk for serious infections, are prospectively documented from birth until discharge home

Secondary Outcome Measures

Name	Time	Method
The effect of acidic and neutral oligosaccharides supplemented enteral nutrition on feeding tolerance, short-term outcome, postnatal adaptation of the gut and modulation of the immune response