The role of mild cold exposure on heat production before and after a glucose load in overweight Australian adults with and without the metabolic syndrome.
Not Applicable
Completed
- Conditions
- Metabolic syndromeMetabolic and Endocrine - Other metabolic disorders
- Registration Number
- ACTRN12612000509864
- Lead Sponsor
- Mario Soares
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 48
Inclusion Criteria
Australians of European origin; overweight or obese with a body mass index (BMI) of greater than 25 kg/m2, weight stable within +/- 2 kg in the previous 6 months with no intention for weight loss within the next 6 months, with or without the metabolic syndrome.
Exclusion Criteria
Fever, thyroid disease (by history); polycystic ovarian syndrome (by history); type II diabetes (by history); smoking; pregnancy; lactation; use of thermogenic agents; hormonal contraception; testosterone replacement
therapy; hormonal replacement therapy and women who are peri-menopausal.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Resting energy expenditure before and after a glucose load. This in measured by monitoring the participants expired air, by placing a transparent canopy over their head while they rest in bed. The expired air content of oxygen and carbon dioxide is measured by a special machine called the Deltatrac II, and these values are converted to rates of energy expendiure by the principle of indirect calorimetry.[Measurements will be made at 30 min and 60 min after entering the chamber, followed by measurements every 30 min after the glucose load for a period of 2 hr. In total 6 measurements of 20 min each will be required.]
- Secondary Outcome Measures
Name Time Method Body temperature at rest and after a glucose load. In the ear hand held thermometers will record core body temperature. Surface temperatures of different locations of the body will be continuously monitored by using special ibuttons (the size of a 10 cent coin) that are attached to the body with special tape. These devices are not wired.[In the ear temperature measurements will be made at 30 min and 60 min after entering the chamber, followed by measurements every 30 min after the glucose load for a period of 2 hr. In total 6 measurements will be made. The ibuttons provide a continuous recording of surface temperature in their location.];Plasma Adiponectin at rest and after a glucose load. Adiponectin is a protein carried in blood that has beneficial effects on human metabolism. We will collect 6 ml of blood, process and freeze the sample for measurement on completion of the trial.[60 min after entering the chamber and 2 hr after the glucose load. In total 2 measurements.]